Our lab is interested in epigenetic gene regulation in mammalian development and in ageing. Global epigenetic reprogramming occurs at fertilisation and fundamentally remodels the epigenomes of sperm and egg.

Dr. Wolf Reik is the Director of the Altos Cambridge Institute of Science. Wolf was previously Head of the Epigenetics Programme and subsequently Director of the Babraham Institute in Cambridge. He is also an honorary Professor of Epigenetics at the University of Cambridge.

Professor Wolf Reik Epigenetic reprogramming in mammalian development. Laboratory Location: Babraham Institute Research. Epigenetic modifications such as DNA methylation and histone marks are often relatively stable in differentiated and in adult tissues in the body, where they help to confer a stable cell identity on tissues.

Mar 25, 2021 · Professor Wolf Reik (credit: Babraham Institute) He discovered the key molecular mechanisms of genomic imprinting and of epigenetic reprogramming. His research focuses on understanding the epigenetic mechanisms governing mammalian development and ageing.

Wolf Reik. Head, Epigenetics Programme, Babraham Institute Cambridge, UK. Verified email at babraham.ac.uk - Homepage. Epigenetics reprogramming development. Articles Cited by Public access Co-authors. Title. Sort. Sort by citations Sort by year Sort by title. Cited by. Cited by. Year; Evolution and functions of long noncoding RNAs.

Wolf Reik is interested in epigenetic gene regulation in mammalian development. His current research focuses on epigenetic heterogeneity in development and ageing, making use of single cell genomics. He is a founding member of the Single Cell Genomics Centre since 2013.

DJ Bolland, MR King, W Reik, AE Corcoran, C Krueger , 3D DNA FISH has become a major tool for analyzing three-dimensional organization of the nucleus, and several variations of the technique have been published.

Jan 19, 2022 · Professor Wolf Reik will move to lead the new Altos Cambridge Institute of Science. Professor Reik has spent 34 years at the Institute, serving as Head of the Epigenetics Programme from 2008-2020 and as Acting Director and then Director from 2020-2021.

Professor Wolf Reik is the Director of the Babraham Institute and Professor of Epigenetics at the University of Cambridge. His research interests focus on epigenetic gene regulation in mammalian development with his early work leading to the discovery of epigenetic imprinting.

Feb 2, 2010 · In a recent conversation, Reik confessed to daydreams of a clinical practice while he focuses on the basic mechanisms behind epigenetic reprogramming. That reverie, he explains, is sated by collaborative projects that bring together his molecular studies and epigenetics-related human disorders.

Wolf Reik's 579 research works with 71,298 citations and 17,710 reads, including: Maternal SMARCA5 is required for major ZGA in mouse embryos

Since March 2022, he is the founding director of the Altos Labs Cambridge Institute of Science. The research interests of his lab are in epigenetics, particularly in epigenetic reprogramming during mammalian development and its role in stem cell biology, inheritance, and aging.

Wolf Reik obtained his MD from the University of Hamburg. He did his thesis work with Rudolf Jaenisch, and postdoctoral work with Azim Surani in Cambridge. He became a Fellow of the Lister Institute of Preventive Medicine at Cambridge and subsequently the Head of the Epigenetics Programme at the Babraham Institute in Cambridge and its Associate ...

Wolf Reik obtained his MD from the University of Hamburg. He did his thesis work with Rudolf Jaenisch, and postdoctoral work with Azim Surani in Cambridge. He was a Fellow of the Lister Institute of Preventive Medicine at Cambridge and the Institute’s Associate Director (2004-2020) and Head of the Epigenetics Programme (2008-2020).

Wolf Reik is a molecular biologist who has made a series of spectacular discoveries relating to the control system — known as epigenetics — that normally ensures the stable expression of our genes.

At the Babraham Institute, where he's been for 15 years now, Reik has delved into the molecular aspects of epigenetics and its role in imprinting (1)—the developmental control of gene expression based on a gene's maternal vs. paternal origin.

Sep 6, 2023 · Conclusions: We revealed the distinct characteristics between Siglec-15 + tumor cells and TAMs in relation to CD8 + T cells, and a unique relationship between Siglec-15 and immunosuppressive TIME in LUAD, which may provide potential value for anti-Siglec-15 therapy.

Mar 18, 2022 · To further optimize the repair effect of ACNGs, in this study, we used a composite technology based on supercritical carbon dioxide (scCO 2) extraction to process the peripheral nerve of a large mammal, the Yorkshire pig, and obtained an innovative Acellular nerve xenografts (ANXs, namely, CD + scCO 2 NG).

Mar 11, 2024 · Our meta-analysis of fourteen randomized controlled trials compared traditional Chinese medicine containing hawthorn with conventional lipid-lowering drugs for hyperlipidemia.

Sep 16, 2023 · Taking the pilot policy of energy-consuming right trading (ECRT) of China in 2016 as a quasi-natural experiment, this paper uses the difference-in-differences (DID) method to investigate the policy impact of ECRT on the economic …