2024年12月25日 · WNT4 (Wnt Family Member 4) is a Protein Coding gene. Diseases associated with WNT4 include 46,Xx Sex Reversal With Dysgenesis Of Kidneys, Adrenals, And Lungs and Mullerian Aplasia And Hyperandrogenism. Among its related pathways are ncRNAs involved in Wnt signaling in hepatocellular carcinoma and Wnt Pathway.

The WNT4 gene belongs to a family of WNT genes that play critical roles in development before birth. Learn about this gene and related health conditions.

2021年10月12日 · WNT4 is a promoter in osteogenic differentiation in bone marrow stromal cells (BMSCs) by participating in bone homeostasis regulation in osteoporotic diseases. Non-canonical WNT4 signaling is...

2025年3月3日 · The WNT4 gene suppresses male sex differentiation pathways and promotes the formation of Müllerian duct structures, including the uterus and fallopian tubes, which are need for female sexual development. WNT4 deficiency may cause significant psychological challenges and counseling is recommended.

2025年2月8日 · Wnt4 gene, a member of the Wnt-beta-catenin pathway, was identified as a target gene of MM-1. WNT4 is involved in the regulation of mullerian duct development and ovarian androgen biosynthesis. WNT4 may also contribute to …

The WNT4 gene provides instructions for producing a protein that is important for the formation of the female reproductive system, the kidneys, and several hormone- producing glands.

WNT4 regulates breast and gynecologic cancer metabolism via a previously unappreciated intracellular signaling mechanism at the mitochondria, with WNT4 mediating metabolic remodeling.

2011年11月10日 · We report that Wnt4 was necessary for normal thymocyte and TEC numbers, as well as for the establishment of a proper medulla during fetal thymopoiesis and postnatal thymic expansion.

Here, we identify the importance of signaling between β-cells via the extracellular signal WNT4. We show heterogeneity in Wnt4 expression, most strikingly in the postnatal maturation period, Wnt4 -positive cells, being more mature while Wnt4- negative cells are more proliferative.

In this study, our aim was to clarify the pathophysiological role and mechanisms of Wnt4 following acute cardiac ischemic reperfusion injury.