Protein Wnt-3a is a protein that in humans is encoded by the WNT3A gene. [5] The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have are critical in tissue homeostasis, embryonic development, and disease.

2015年9月14日 · Wnt3a, one of Wnt family members, plays key roles in regulating pleiotropic cellular functions, including self-renewal, proliferation, differentiation, and motility. Accumulating evidence has suggested that Wnt3a promotes or suppresses tumor progression via the canonical Wnt signaling pathway depending on cancer type.

2024年12月25日 · WNT3A (Wnt Family Member 3A) is a Protein Coding gene. Diseases associated with WNT3A include Hypophosphatasia, Adult and Short Stature And Advanced Bone Age With Or Without Early-Onset Osteoarthritis And/Or Osteochondritis Dissecans. Among its related pathways are ncRNAs involved in Wnt signaling in hepatocellular carcinoma and …

2022年1月3日 · Three key signalling molecules in the Wnt/β-catenin signalling pathway—Wnt3a, β-catenin, and Cyclin D1—are upregulated at the mRNA and protein levels in the adult spinal cord of SOD1...

WNT3A is a component of the Wnt/β-catenin signaling pathway, which is involved in cell-cell adhesion as well as stimulation of oncogenic factors such as c-Myc and CCND1. From: Molecular Therapy - Nucleic Acids, 2022

2025年2月8日 · WNT3A putatively associates with primary osteoporosis. WNT3A promoted MSC proliferation via the ss-catenin-mediated canonical Wnt pathway, and inhibited chondrogenesis of mesenchymal stem cells via the calcium/calmodulin-dependent kinase II (CaMKII)-mediated non-canonical Wnt pathway.

Wnt3a is an attractive candidate target for therapeutic intervention in the pathogenesis of cancer. In this review, we summarized roles of the Wnt3a ligand in the pathogenesis of different cancers including colorectal, prostate, hepatocellular carcinoma, lung cancer and leukemia.

2015年9月14日 · Wnt3a, one of Wnt family members, plays key roles in regulating pleiotropic cellular functions, including self-renewal, proliferation, differentiation, and motility. Accumulating evidence has suggested that Wnt3a promotes or suppresses tumor progression via the canonical Wnt signaling pathway depending on cancer type.

2025年1月14日 · Wnt3a induced Id3 expression in a beta-catenin-dependent manner. Wnt3a stimulates Mepe transcription directly by a canonical Wnt signaling pathway through beta-catenin and Lef-1 and indirectly through the activation of a Bmp-2 autocrine loop.

Wnt3a, one of Wnt family members, plays key roles in regulating pleiotropic cellular functions, including self-renewal, proliferation, differentiation, and motility. Accumulating evidence has suggested that Wnt3a promotes or suppresses tumor ...