Inhibition of Wnt signalling by Notch via two distinct mechanisms …
2021年4月27日 · Notch and Wnt are two essential signalling pathways that help to shape animals during development and to sustain adult tissue homeostasis. Although they are often active at the same time...
The interaction of Notch and Wnt signaling pathways in …
2021年4月1日 · In this review, we summarize the roles of Notch signaling and Wnt signaling during several representative organ regenerative events, emphasizing the functions and molecular bases of their interplay in these processes, shedding light on utilizing these two signaling pathways to enhance regeneration in mammals and design legitimate therapeutic ...
Notch-Wnt signal crosstalk regulates proliferation and ... - Nature
2021年5月28日 · Here, we dissect the temporal and spatial role of Notch and Wnt signaling during intramembranous bone formation, and by using molecular pathway manipulation, we identify an interaction...
Targeting Wnt/β-catenin signaling and its interplay with TGF-β …
This review will discuss the role of the TGF-β, Notch, and Wnt/β-catenin signaling pathways in wound healing, with a special focus on the Wnt/β-catenin signaling pathway in the different phases of wound healing.
Notch signaling pathway: architecture, disease, and therapeutics
2022年3月24日 · In this review, we focus on both classical and the latest findings related to NOTCH signaling to illustrate the history, architecture, regulatory mechanisms, contributions to physiological...
The Role of Notch, Hedgehog, and Wnt Signaling Pathways in …
2021年4月21日 · We present a brief overview of Notch, Hedgehog, and Wnt signaling pathways in cancer and its role in providing resistance to various cancer treatment modalities such as chemotherapy, radiotherapy, molecular targeted therapy, and immunotherapy.
ROS, Notch, and Wnt Signaling Pathways: Crosstalk between …
2014年2月4日 · Different authors provided scientific evidences regarding a sequential and direct link between Notch and Wnt signaling pathways in tuning endothelial cells (ECs) and cardiomyocytes functions and vascular morphogenesis [ 4 ]. The purpose of this review is to describe how ROS regulate Notch and Wnt pathways.
Wnt and Notch signaling pathway involved in wound healing …
2015年6月16日 · We employed a self-controlled model (Sprague–Dawley rats with full-thickness skin wounds) to observe the action and effect of Wnt/β-catenin and Notch signalings in vivo. The quality of wound repair relevant to the gain/loss-of-function Wnt/β-catenin and Notch activation was estimated by hematoxylin-and-eosin and Masson staining.
Notch and Wnt signaling pathway in cancer: Crucial role and …
2015年12月7日 · In the present review, we mainly discuss the components and mechanisms of activation of the Notch and Wnt signaling pathways, and we summarize the recent research efforts on these two pathways in different cancers.
Wnt-Notch signalling crosstalk in development and disease
The Notch and Wnt pathways are two of only a handful of highly conserved signalling pathways that control cell-fate decisions during animal development (Pires-daSilva and Sommer in Nat Rev Genet 4: 39-49, 2003). These two pathways are required together to regulate many aspects of metazoan developmen …
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