Protein Wnt-3a is a protein that in humans is encoded by the WNT3A gene. [5] The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have are critical in tissue homeostasis, embryonic development, and disease.

Wnt3a, an important member of the Wnt family, activates the canonical Wnt signaling pathway to exhibit its biological functions. It is mainly involved in embryonic development, neural development, cell differentiation, proliferation, and tumorigenesis.

2015年9月14日 · Wnt3a, one of Wnt family members, plays key roles in regulating pleiotropic cellular functions, including self-renewal, proliferation, differentiation, and motility. Accumulating evidence has suggested that Wnt3a promotes or suppresses tumor progression via the canonical Wnt signaling pathway depending on cancer type.

2022年1月3日 · Extracellular signals are mainly mediated by Wnt proteins, including Wnt3a, Wnt1, and Wnt5a. The cell membrane segment mainly contains the Wnt receptors Frizzled (specific sevenfold...

2019年6月24日 · Wnt3a is an attractive candidate target for therapeutic intervention in the pathogenesis of cancer. In this review, we summarized roles of the Wnt3a ligand in the pathogenesis of different cancers including colorectal, prostate, hepatocellular carcinoma, lung cancer and leukemia.

2015年9月14日 · Herein, we summarize the latest findings on Wnt3a as an important therapeutic target in cancer. Wnt3a, one of Wnt family members, plays key roles in regulating pleiotropic cellular functions, including self-renewal, proliferation, differentiation, and motility.

2024年12月25日 · WNT3A (Wnt Family Member 3A) is a Protein Coding gene. Diseases associated with WNT3A include Hypophosphatasia, Adult and Short Stature And Advanced Bone Age With Or Without Early-Onset Osteoarthritis And/Or Osteochondritis Dissecans .

2025年2月8日 · Wnt-3a increases neurogenesis during the differentiation of ReNcell VM cells. Neurogenesis induced by Wnt-3a is independent of the transcriptional activity of Wnt/beta-catenin pathway in ReNcell VM cells.

2025年1月14日 · Wnt-3a increases cell proliferation and differentiation of neural progenitor cells from postnatal and adult mice brain. Results suggest that Wnt-3a inhibits chondrogenesis by stabilizing cell-cell adhesion and that it causes dedifferentiation of chondrocytes by activation of beta-catenin-Tcf/Lef transcriptional complex and the c-Jun/AP-1 pathway.

2025年2月8日 · This gene is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region.