Wee1 is a nuclear kinase belonging to the Ser/Thr family of protein kinases in the fission yeast Schizosaccharomyces pombe (S. pombe). Wee1 has a molecular mass of 96 kDa and is a key regulator of cell cycle progression. [1] It influences cell size by inhibiting the entry into mitosis, through inhibiting Cdk1.

Dec 25, 2024 · WEE1 (WEE1 G2 Checkpoint Kinase) is a Protein Coding gene. Diseases associated with WEE1 include Breast Cancer and Ciliary Dyskinesia, Primary, 20. Among its related pathways are Mitotic G1 phase and G1/S transition and HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA).

Wee1 is the principal gatekeeper for both G2/M and S-phase checkpoints, where it plays a key role in cell cycle regulation and DNA damage repair.

Mar 7, 2024 · Based on the phospho-signature, we pinpoint CDK1 kinase is hyperactivated during hyperthermia, influencing the global signaling landscape. We observe dynamic, reversible CDK1 activity, causing...

Sep 21, 2020 · This review recapitulates and discusses the most recent findings on the biological function of WEE1/PKMYT1 during the cell cycle and in the DNA damage repair, with a focus on their dual role as tumor suppressors in nonmalignant cells and pseudo-oncogenes in cancer cells.

Oct 1, 2013 · Wee1, a protein kinase, regulates the G 2 checkpoint in response to DNA damage. Preclinical studies have elucidated the role of wee1 in DNA damage repair and the stabilization of replication forks, supporting the validity of wee1 inhibition as a viable therapeutic target in cancer.

Jan 12, 2023 · The deacetylase SIRT1 directly associates with and modifies WEE1 to inactivate it enabling resistance to WEE1 inhibition in cancer cells.

The WEE1 kinase was identified as an important regulator during S phase, preventing entry into mitosis until DNA replication has been completed. Interestingly, WEE1 has also emerged as a key player in regulating histone synthesis.

Jan 1, 2022 · Therefore, inhibition of WEE1 kinase could sensitize cancer cells to chemotherapeutic drugs. This review focuses on the role of WEE1 kinase (as a biological macromolecule which has a molecular mass of 96 kDa) in the cell cycle, and its interactions with other regulatory pathways.

Feb 11, 2021 · It is well known that the evolutionarily conserved protein kinase WEE1 regulates replication stress responses by directly phosphorylating and inhibiting the major cell cycle driver CDKs in many...

Wee1 is a tyrosine kinase that is known to be overexpressed in many cancer types such as luminal and HER2-positive breast cancer subtypes, hepatocellular carcinomas, and glioblastomas (Iorns et al., 2009). Wee1 directly interacts with histone H2B to halt histone transcription at the end of S phase.

Jun 1, 2022 · The expanding role of WEE1 in pathophysiology is matched by the keen surge of interest in developing WEE1-targeted therapeutic agents. This review summarises WEE1 involvement in the cell cycle checkpoints, epigenetic modification and immune signalling, as well as the current state of WEE1 inhibitors in cancer therapeutics.

Here, we review how WEE1 regulates cell-cycle progression highlighting the importance of this kinase for proper S phase. We discuss how its function is modulated throughout different cell-cycle stages and provide an overview of how WEE1 levels are regulated.

Sep 21, 2020 · This review recapitulates and discusses the most recent findings on the biological function of WEE1/PKMYT1 during the cell cycle and in the DNA damage repair, with a focus on their dual role as tumor suppressors in nonmalignant cells and pseudo-oncogenes in cancer cells.

Dec 13, 2021 · In this in silico study, we assessed the structural conservation of the WEE1 protein in the plant kingdom with a particular focus on agronomically valuable plants, the legume crops.

Nov 26, 2021 · WEE1 inhibition increases endogenous retroviral elements (ERVs) expression by relieving SETDB1/H3K9me3 repression through down-regulating FOXM1. ERVs trigger dsRNA stress and interferon response, increasing recruitment of anti-tumor T cells with concurrent PD-L1 elevation in multiple tumor models.

Dec 27, 2022 · Wee1 is extensively involved in the DRR signaling and DSB repair pathway. Inhibiting abnormally elevated Wee1 benefits CML therapy in both IM-resistant and IM-sensitive cells.

The expanding role of WEE1 in pathophysiology is matched by the keen surge of interest in developing WEE1-targeted therapeutic agents. This review summarises WEE1 involvement in the cell cycle checkpoints, epigenetic modification and immune signalling, as well as the current state of WEE1 inhibitors in cancer therapeutics.

Aug 14, 2017 · Wee1 is a protein kinase that regulates the G 2 checkpoint and prevents entry into mitosis in response to DNA damage (Fig. 1; ref. 1). The cell cycle is a highly controlled process. There are several mechanisms by which cells can modulate progression through the cell cycle in case of DNA damage or other factors that affect DNA replication.

Jul 14, 2016 · WEE1 is highly expressed and active in several cancer types that depend on a functional G2–M checkpoint for DNA repair. Targeting WEE1 for inhibition and compromising the G2–M checkpoint presents an opportunity to potentiate chemotherapy.