In tumors and other proliferating or developing cells, the rate of glucose uptake dramatically increases and lactate is produced, even in the presence of oxygen and fully functioning mitochondria. This process, known as the Warburg Effect, has …

In oncology, the Warburg effect (/ ˈ v ɑːr b ʊər ɡ /) is the observation that most cancers use aerobic glycolysis and lactic acid fermentation for energy generation rather than the mechanisms used by non-cancerous cells. [1]

2021年1月13日 · New research is revealing the mechanisms regulating the Warburg effect, the balance between oxidation and glycolysis of glucose in cancer cells.

Cancer cells rewire their metabolism to promote growth, survival, proliferation, and long-term maintenance. The common feature of this altered metabolism is the increased glucose uptake and fermentation of glucose to lactate.

Anticancer strategies based on the Warburg effect have involved the use of drug compounds and dietary changes. We recently reviewed applications of the Warburg effect to understand the benefits of this unusual cancer-related metabolism. In the current article, we summarize diet strategies for cancer treatment based on the Warburg effect. 1.

2021年5月21日 · The Warburg Effect Is a Prominent Feature of Cancer Cell Metabolism In 1927, Warburg studied the processes of respiration and fermentation in tumor cells. According to normal cellular respiration, glucose is converted to pyruvate, which then enters the TCA cycle to undergo oxidative phosphorylation in the presence of oxygen, and there should be ...

In contrast to normal differentiated cells, which rely primarily on mitochondrial oxidative phosphorylation to generate the energy needed for cellular processes, most cancer cells instead rely on aerobic glycolysis, a phenomenon termed “the Warburg effect.”

2009年5月22日 · In contrast to normal differentiated cells, which rely primarily on mitochondrial oxidative phosphorylation to generate the energy needed for cellular processes, most cancer cells instead rely on aerobic glycolysis, a phenomenon termed "the Warburg effect."

2011年1月24日 · The best characterized metabolic phenotype observed in tumour cells is the Warburg effect, which is a shift from ATP generation through oxidative phosphorylation to ATP generation through...

2024年3月8日 · The Warburg effect, characterized by the preferential conversion of glucose to lactate even in the presence of oxygen and functional mitochondria, is a prominent metabolic hallmark of cancer cells and has emerged as a promising therapeutic target for cancer therapy.