Vitamin K - StatPearls - NCBI Bookshelf - National Center for ...
2023年7月10日 · Vitamin K is a medication used to manage and treat bleeding due to the coagulation disorder caused by warfarin and vitamin K deficiency. It is in the fat-soluble vitamin class of drugs. This activity outlines the indications, actions, and contraindications for vitamin K as a valuable agent in managing coagulation disorders caused by warfarin or ...
Diverse biological functions of vitamin K: from coagulation to ...
2023年6月19日 · Vitamin K is an essential micronutrient involved in a variety of physiological processes. Chiefly, vitamin K is essential to the blood clotting cascade by serving as a cofactor for the...
Biological Role of Vitamin K—With Particular Emphasis on …
The most known function associated with vitamin K is its participation in the blood coagulation process. Vitamin K is needed for the synthesis and action of coagulation factors, such as factor II, VII, IX and X (the so-called prothrombin complex) and both proteins C and S [1,10].
Overview of vitamin K - UpToDate
Vitamin K has a major role in coagulation pathways because it is a cofactor required for the activity of several key proteins containing carboxyglutamic acid residues. Vitamin K deficiency is rare except in neonates and patients with predisposing conditions including hepatobiliary or pancreatic disease.
Vitamin K and the Vitamin K Dependent Clotting Factors
2024年5月9日 · Vitamin K is fundamental to a post-translational modification [a Vitamin K-dependent carboxylation reaction] that converts specific glutamate residues [Glu] in the Vitamin K dependent protein, to gamma-carboxyglutamate residues [Gla] and the generation of a functionally active protein.
Vitamin K: Double Bonds beyond Coagulation Insights into …
Through post translational modification of glutamate (Glu) residues in coagulation factors, vitamin K enables posttranslational carboxylation, which allows high affinity binding with support of calcium to negatively charged phospholipid membrane areas …
Vitamin K – sources, physiological role, kinetics, deficiency ...
Vitamin K is traditionally connected with blood coagulation, since it is needed for the posttranslational modification of 7 proteins involved in this cascade. However, it is also involved in the maturation of another 11 or 12 proteins that play different roles, encompassing in particular the modulation of the calcification of connective tissues.
Vitamin K is an essential micronutrient involved in a variety of physiological processes. Chiefly, vitamin K is essential to the blood clotting cascade by serving as a cofactor for the...
K is for koagulation - Nature
2004年2月5日 · Vitamin-K-dependent carboxylase uses reduced vitamin K and oxygen to add a carbon dioxide molecule to the side chain of glutamic acid in certain blood-clotting proteins,...
Vitamin K: the effect on health beyond coagulation - an overview
Vitamin K is essential for the synthesis of proteins belonging to the Gla-protein family. To the members of this family belong four blood coagulation factors, which all are exclusively formed in the liver.