VAV1 - Wikipedia
Proto-oncogene vav is a protein that in humans is encoded by the VAV1 gene. [5] The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide …
Vav1: a key signal transducer downstream of the TCR - PubMed
Vav1 is a 95-kDa protein expressed in all hemopoietic cells that becomes rapidly tyrosine phosphorylated following T cell antigen receptor (TCR) stimulation. Vav1 contains multiple …
VAV1 Gene - GeneCards | VAV Protein | VAV Antibody
2024年12月25日 · VAV1 (Vav Guanine Nucleotide Exchange Factor 1) is a Protein Coding gene. Diseases associated with VAV1 include Immunodeficiency 62 and Dyskeratosis Congenita, …
VAV1 as a putative therapeutic target in autoimmune and ...
2024年7月25日 · The guanine nucleotide exchange factor (GEF) VAV1, a previously ‘undruggable’ protein integral to T/B lymphocyte antigen–receptor signaling, promotes actin …
VAV1 vav guanine nucleotide exchange factor 1 [ (human)]
Vav1 Sustains the In Vitro Differentiation of Normal and Tumor Precursors to Insulin Producing Cells Induced by all-Trans Retinoic Acid (ATRA). Cancer-associated mutations in VAV1 trigger …
Vav1 regulates T cell activation through a feedback mechanism ...
Vavl, a Rac/Rho guanine nucleotide exchange factor and a critical component of the T cell receptor (TCR) signaling cascade, is rapidly tyrosine phosphorylated in response to T cell …
Mechanism and function of Vav1 localisation in TCR signalling
The Vav1 guanine nucleotide exchange factor plays a critical role in T cell antigen receptor (TCR) signalling, leading to the activation of multiple pathways. We now show that it is recruited to …