Glutamate transporters are a family of neurotransmitter transporter proteins that move glutamate – the principal excitatory neurotransmitter – across a membrane. The family of glutamate transporters is composed of two primary subclasses: the excitatory amino acid transporter (EAAT) family and vesicular glutamate transporter (VGLUT) family.

Here we report that the vesicular-glutamate transporter 2 (VGLUT2) functions as a specific marker gene for subicular burst-firing neurons, and demonstrate that VGLUT2-Cre mice allow for Channelrhodopsin-2 (ChR2)-assisted connectivity analysis.

2021年6月2日 · Here we show that the subpopulation of midbrain dopaminergic neurons that express the vesicular glutamate transporter 2 (VGLUT2) are more resilient to rotenone-induced neurodegeneration. Rotenone also upregulates VGLUT2 more broadly in the midbrain, suggesting that VGLUT2 expression generally confers increased resilience to rotenone.

The highly homologous protein VGLUT2, also initially characterized as a phosphate transporter and named differentiation-associated Na +-dependent inorganic phosphate transporter (DNPi), has a nearly complementary pattern of expression with one of the two proteins present in all established glutamatergic neurons. In general, VGLUT1 predominates ...

2006年11月15日 · Three transporters (VGLUT1-VGLUT3) are expressed in the mammalian CNS, with partial overlapping expression patterns, and VGLUT2 is the most abundantly expressed paralog in the thalamus, midbrain, and brainstem.

2020年5月30日 · VGLUT1 and VGLUT2 are expressed in distinct and complementary subsets of neurons in the CNS that display differences in release probability [36, 39]. VGLUT1 is the most abundant subtype in the CNS [ 47 ].

2020年5月8日 · Vesicular glutamate transporter-2 (VGLUT2)-expressing neurons in the VNC have a crucial role in vestibular system-related thermoregulation. Our experiments first...

2006年11月15日 · We show that targeted deletion of VGLUT2 in mice causes perinatal lethality and a 95% reduction in evoked glutamatergic responses in thalamic neurons, although hippocampal synapses function normally.

2023年5月11日 · In the mammalian central nervous systems, three vesicular glutamate transporters (VGLUT1, VGLUT2 and VGLUT3) are responsible for filling the synaptic vesicles of excitatory neurons with...

We report that conditional knockout (cKO) of the Slc17a6 gene encoding VGLUT2 from the great majority of nociceptors profoundly decreased VGLUT2 mRNA and protein in these neurons, and reduced firing of lamina I spinal cord neurons in response to …