The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport.

Dec 22, 2017 · Here, we show by live-cell imaging with pH- and chloride-sensitive fluorescent probes in cultured hippocampal neurons of wild-type and VGLUT1-deficient mice that in SVs VGLUT functions as a...

May 11, 2023 · In summary, we provide evidence that VGLUT1 functions as H + -glutamate exchanger that is partially or fully uncoupled by other anions. Synaptic vesicles accumulate neurotransmitters via...

Mar 4, 2020 · VGLUT1 transport glutamate (Glu) mechanism diagram. VGLUT1 use proton electrochemical gradient generated by vascular ATPase to carry the glutamata anion (Glu) into the interior of synaptic vesicles. The outflow of chloride ions in synaptic vesicles increases the transport efficiency of VGLUT1.

May 30, 2020 · Three subtypes of vesicular glutamate transporters (VGLUT1–3) have been identified that package glutamate into vesicles [34, 35, 36, 37, 38, 39, 40, 41, 42] reviewed in [43, 44, 45, 46].

Mar 18, 2011 · Vesicular glutamate transporter 1 (Vglut1) mRNA is found mostly in the cerebral cortex and hippocampus, and Vglut2 mRNA is found mostly in subcortical structures, including the thalamus and...

Exocytotic release of glutamate depends upon loading of the neurotransmitter into synaptic vesicles by vesicular glutamate transporters, VGLUTs. The major isoforms, VGLUT1 and 2, exhibit a complementary pattern of expression in synapses of the adult ...

Dec 1, 2011 · Vesicular glutamate transporter 1 (VGLUT1) is widely distributed in the central nervous system of most mammalian and nonmammalian species, and regulates the uptake of glutamate into synaptic vesicles as well as the transport of filled glutamatergic vesicles to the terminal membrane during excitatory transmission.

Mar 15, 2018 · Remarkably, VGLUT1 knockdown alleviated the rapid antidepressant-like actions of scopolamine and the effects of scopolamine on membrane GluA1-mediated BDNF, VGF and BICC1 changes.

Feb 12, 2025 · VGLUT1, a vesicular glutamate transporter, is vital for neurotransmitter release and synaptic communication. Its role in packaging glutamate into synaptic vesicles directly …