The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport.

Finally, VGLUT1 and VGLUT2 can be considered as valuable and highly specific markers of canonical glutamatergic neurons with the inherent limitation that the cell body is not co-stained, making cellular assignment of synaptic staining patterns difficult.

2024年12月25日 · Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate (PubMed: 10820226).

VGluT1 Deficiency Impairs Visual Attention and Reduces the Dynamic Range of Short-Term Plasticity at Corticothalamic Synapses. Lindström SH, Sundberg SC, Larsson M, Andersson FK, Broman J, Granseth B

Polyclonal Antibody for studying VGLUT1. Validated for WB. Highly specific and rigorously validated in-house, VGLUT1 Antibody (CST #12331) is ready to ship.

2020年5月30日 · Three subtypes of vesicular glutamate transporters (VGLUT1–3) have been identified that package glutamate into vesicles [34, 35, 36, 37, 38, 39, 40, 41, 42] reviewed in [43, 44, 45, 46].

2020年3月4日 · VGLUT1 transport glutamate (Glu) mechanism diagram. VGLUT1 use proton electrochemical gradient generated by vascular ATPase to carry the glutamata anion (Glu) into the interior of synaptic vesicles. The outflow of chloride ions in synaptic vesicles increases the transport efficiency of VGLUT1.

2014年10月15日 · The interaction of a VGLUT1 polyproline domain with the endocytic protein endophilin recruits VGLUT1 to a fast recycling pathway. To identify trans-acting cellular proteins that interact with the distinct motifs found in the C-terminus of VGLUT1, we performed a series of in vitro biochemical screening assays using the region encompassing the ...

2025年2月12日 · VGLUT1, a vesicular glutamate transporter, is vital for neurotransmitter release and synaptic communication. Its role in packaging glutamate into synaptic vesicles directly affects brain health by influencing neuronal signal transmission.

SLC17A7 is a gene that encodes the protein vesicular glutamate transporter 1 (VGLUT1). This protein is found in the brain and is responsible for transporting glutamate, an important neurotransmitter, into synaptic vesicles.