2024年12月25日 · VDAC1 (Voltage Dependent Anion Channel 1) is a Protein Coding gene. Diseases associated with VDAC1 include Acute Cervicitis and Acute Gonococcal Cervicitis. Among its related pathways are Selective autophagy and Alzheimer's disease and miRNA effects.

The voltage-dependent anion channel 1 (VDAC1) protein, is an important regulator of mitochondrial function, and serves as a mitochondrial gatekeeper, with responsibility for cellular fate. In addition to control over energy sources and metabolism, ...

VDAC1 is the gatekeeper for the passages of metabolites, nucleotides, and ions; it plays a crucial role in regulating apoptosis due to its interaction with apoptotic and anti-apoptotic proteins, namely members of the Bcl-2 family of proteins and hexokinase.

2020年10月26日 · The voltage-dependent anion channel 1 (VDAC1) protein, is an important regulator of mitochondrial function, and serves as a mitochondrial gatekeeper, with responsibility for cellular fate.

The overexpression of VDAC1 in highly glycolytic cancer cells prompted us to develop a workflow for the identification of chemical entities able to decrease energy production in cancer cells. VDAC1 is a β-barrel channel constituted by 19 anti-parallel β-strands and an …

2024年12月30日 · Voltage-Dependent Anion Channel 1 (VDAC1) is a mitochondrial outer membrane protein that plays a crucial role in regulating cellular energy metabolism and apoptosis by mediating the exchange of ions and metabolites between mitochondria and the cytosol.

Data show that voltage-dependent anion channel 1 (VDAC1) knockout cells are resistant to AMP-activated protein kinase (AMPK) and mechanistic target of rapamycin (mTOR) modulation by itraconazole, indicating VDAC1 is the mediator of the activity.

2021年6月3日 · Complex formation between hexokinase-II (HKII) and the mitochondrial VDAC1 is crucial to cell growth and survival. We hypothesize that HKII first inserts into the outer membrane of mitochondria...

2024年12月30日 · Voltage-Dependent Anion Channel 1 (VDAC1) is a mitochondrial outer membrane protein that plays a crucial role in regulating cellular energy metabolism and apoptosis by mediating the exchange of ions and metabolites between mitochondria and the cytosol.

VDAC1 controls the flux of magnesium, chloride and potassium ions across the MOM, as well as of calcium, participating in the maintenance of cytosolic Ca 2+ level in the physiological range. Evidence highlighted that VDAC1 acts as a preferential release channel for the hydrophilic ROS superoxide anion, produced during respiration by OXPHOS.