Beta-hydroxybutyrate (BHB) is a chemical that is made by the body. It provides energy when not enough carbohydrates or sugars have been eaten. BHB can also be made in the...

Dec 18, 2024 · β-羟丁酸（bhb）是一种在人体代谢过程中产生的内源性物质，尤其在禁食、长时间超负荷运动或长期缺乏碳水化合物时，肝脏会利用脂肪代谢产生大量的bhb。

Here, we review the signaling activities of the endogenous metabolite β-hydroxybutyrate (BHB). BHB is the most abundant ketone body in mammals. Ketone bodies are small molecules synthesized primarily in the liver from fats that circulate through the bloodstream during fasting, prolonged exercise, and when carbohydrates are restricted.

Jan 9, 2025 · β-Hydroxybutyrate (BHB) is an abundant ketone body. To date, all known pathways of BHB metabolism involve the interconversion of BHB and primary energy intermediates. Here, we identify a previously undescribed BHB secondary metabolic pathway via CNDP2-dependent enzymatic conjugation of BHB and free amino acids.

BHB-P是组蛋白去乙酰化酶（HDACs）的内源性抑制剂，可以改变NAD/NADH和Q/QH2偶联并减少线粒体活性氧的产生，上调参与保护氧化应激和调节代谢的基因 。 同时，β-羟基丁酸（BHB）能够通过hnRNP A1介导的Oct4上调来防止血管细胞衰老。 炎症小体（inflammasome ）会促进细胞因子前体pro-IL-1β和pro-IL-18的成熟和分泌、诱导细胞在炎性和应激的病理条件下死亡，现已发现有5种炎症小体，即NLRP1、NLRP3、NLRC4、IPAF和AIM2炎性小体。

Here we report that an oral D-beta-hydroxybutyrate (D-BHB) supplement is rapidly absorbed and metabolized in humans and increases blood ketones to millimolar levels. At the same dose, D-BHB is significantly more ketogenic and provides fewer calories than a racemic mixture of BHB or medium chain triglyceride.

bhb 补充剂为研究开辟了令人兴奋的途径，包括研究分子机制、改进优化策略、探索创新机会以及评估健康寿命和寿命益处。 BHB 补充剂代表了健康研究的新前沿，为提高

The ketone bodies β-hydroxybutyrate (BHB) and acetoacetate (AcAc) support mammalian survival during states of energy deficit by serving as alternative sources of ATP. BHB levels are elevated by starvation, caloric restriction, high-intensity exercise, or …

Nov 13, 2024 · β-羟基丁酸 （β-hydroxybutyrate， BHB） 是哺乳动物体内大量存在的一种酮体。 鉴于BHB对于肥胖、糖尿病、癌症、以及与年龄相关的慢性疾病具有潜在的改善效果，近年来通过禁食、长时间运动、营养酮症等方式增加BHB的研究引起广泛关注。 目前已知的所有BHB的代谢通路都是BHB与初级代谢产物之间的相互转化，为直接合成ATP提供能量。 当葡萄糖供应不足、脂肪分解增加时，BHB在肝脏中合成并向外周组织输送能量。 大脑和心脏等组织随即通过分 …

b-Hydroxybutyrate (BHB) is an abundant ketone body. To date, all known pathways of BHB metabolism involve the interconversion of BHB and primary energy intermediates. Here, we identify a previously unde-scribed BHB secondary metabolic pathway via CNDP2-dependent enzymatic conjugation of BHB and free