UNC5B Gene - GeneCards | UNC5B Protein | UNC5B Antibody
Dec 25, 2024 · UNC5B (Unc-5 Netrin Receptor B) is a Protein Coding gene. Diseases associated with UNC5B include Hyperinsulinemic Hypoglycemia, Familial, 3 and Epilepsy. Among its …
A ligand-insensitive UNC5B splicing isoform regulates ... - Nature
Aug 11, 2021 · We show that UNC5B-Δ8 is a constitutively pro-apoptotic splicing isoform insensitive to Netrin-1 and required for specific blood vessel development in an apoptosis …
The netrin receptor UNC5B mediates guidance events controlling …
Oct 27, 2004 · We show here that the repulsive netrin receptor UNC5B is expressed by endothelial tip cells of the vascular system. Disruption of the Unc5b gene in mice, or of Unc5b …
Endothelial Unc5B controls blood-brain barrier integrity
Mar 4, 2022 · Here, we show that the endothelial Unc5B receptor controls BBB integrity by maintaining Wnt/β-catenin signaling. Inducible endothelial-specific deletion of Unc5B in adult …
Nature Communications：耶鲁大学最新研究，揭开血脑屏障分子 …
近日，美国耶鲁大学的研究人员在 Nature Communications 期刊发表了题为：Endothelial Unc5B controls blood-brain barrier integrity 的研究论文。 该研究首次揭开了调控血脑屏障的分子机 …
UNC5B unc-5 netrin receptor B [ (human)] - National Center for ...
Jan 4, 2025 · UNC5B mediates G2/M phase arrest of bladder cancer cells by binding to CDC14A and P53. Long non-coding RNA PITPNA-AS1 regulates UNC5B expression in papillary thyroid …
unc-5 netrin 受体 B（UNC5B）基因 | MCE - MCE-生物活性分子大师
这种特殊的蛋白质介导 netrin-1 的排斥作用，是一种血管 netrin 受体。 这种编码的蛋白质也属于一组称为依赖性受体 (DpRs) 的蛋白质，它们参与促凋亡和抗凋亡过程。 许多 DpR 参与胚胎发 …
Biochem Biophys Res Commun：研究进一步揭示UNC5B在骨生成 …
UNC-5 netrin受体B（UNC5B）是netrin-1的依赖性受体，在介导血管生成和肿瘤发生中起重要作用。 尽管UNC5B具有如此重要的作用，但目前对UNC5B在骨生成中所起的作用仍知之甚少。
Unc5b prevents macrophage-derived foam cell migration and …
Jan 15, 2025 · The transmembrane receptor Unc5b, a vascular-specific axon guidance receptor, is upregulated in foam cells, and inhibits their migration from the plaques. However, the …
Autoinhibition of UNC5b Revealed by the Cytoplasmic Domain …
Mar 27, 2009 · To provide a foundation for the elucidation of the UNC5-mediated signaling mechanism, we determined the crystal structure of the cytoplasmic portion of UNC5b. We …