2024年12月25日 · ULK1 (Unc-51 Like Autophagy Activating Kinase 1) is a Protein Coding gene. Diseases associated with ULK1 include Overnutrition and Neurodegeneration With Brain Iron Accumulation. Among its related pathways are Autophagy and Selective autophagy.

The ULK1 complex consists of ULK1, FIP200, ATG13 and ATG101 and regulates initiation of autophagosome formation. Lack of one or more ULK1 complex components results in impaired autophagy in response to stimuli.

The ULK1 complex initiates autophagosome formation, linking cellular nutrient status to downstream events in autophagy. Recent work suggests that the ULK1 complex might also be activated in selective autophagy independent of nutrient or energy ...

2018年8月28日 · Here, we report that ULK1, a central kinase of the ULK1 complex involved in autophagy initiation, promotes autophagosome–lysosome fusion. PKCα phosphorylates ULK1 and prevents autolysosome ...

2021年10月15日 · Here we show that ULK1 phosphorylates the BNIP3 mitochondrial cargo receptor on a critical serine residue (S17) adjacent to its amino terminal LIR motif. ULK1 similarly phosphorylates BNIP3L on...

2018年8月9日 · UNC-51-like kinase 1 (ULK1), known as an ortholog of the yeast Atg1, is the serine-threonine kinase and the autophagic initiator in mammals. Accumulating evidence has recently revealed the kinase domain structure of ULK1 and its post-translational modifications, as well as further elucidated its reg …

2017年12月12日 · In this artcile, we focus on the regulation of the ULK1 complex during autophagy initiation. The complex pattern of upstream pathways that converge on ULK1 suggests that this complex acts as a node, converting multiple signals into autophagosome formation.

ULK1 contributes to mTORC1 inhibition through hindrance of substrate docking to Raptor. ULK1 represents a novel and clinically useful biomarker for esophageal squamous cell carcinoma (ESCC) patients and plays an important role during the progression of ESCC.

The Atg1/ULK1 complex plays a central role in starvation-induced autophagy, integrating signals from upstream sensors such as MTOR and AMPK and transducing them to the downstream autophagy pathway. Much progress has been made in the last few years ...

Monoclonal Antibody for studying ULK1. Validated for IP, WB, WB. Available in 2 sizes. Highly specific and rigorously validated in-house, ULK1 (D8H5) Rabbit Monoclonal Antibody (CST #8054) is ready to ship.