This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases.

2024年12月25日 · UGT1A9 (UDP Glucuronosyltransferase Family 1 Member A9) is a Protein Coding gene. Diseases associated with UGT1A9 include Crigler-Najjar Syndrome, Type Iiand Crigler-Najjar Syndrome, Type I.

2025年2月19日 · UGT1A9 is the major isoform responsible for the glucuronidations of fraxetin in liver microsomes.

该基因编码一种 UDP-葡萄糖醛酸转移酶，一种葡萄糖醛酸化途径的酶，可将类固醇、胆红素、激素和药物等亲脂性小分子转化为水溶性、可分泌的代谢物。 该基因是编码多种 UDP-葡糖醛酸转移酶的复杂基因座的一部分。 该基因座包括十三个独特的备用第一外显子，后跟四个共同外显子。 四个交替的第一外显子被认为是假基因。 其余九个 5' 外显子中的每一个都可以剪接至四个共同外显子，从而产生具有不同 N 末端和相同 C 末端的九种蛋白质。 每个第一外显子编码底物结合 …

UGT1A9主要表达于肝脏、肾脏，底物有毒物 (如酚类N-羟芳香胺，N-羟萘胺，蒽醌)内源性物质 (如雌激素，类固醇)和一些药物 (如地西泮、香豆素、麦考酚酸等)。

In the present study, the UDP-glucuronosyltransferase (UGT) 1A9 enzyme is identified as a PPARα and PPARγ target gene. UGTs catalyze the glucuronidation reaction, which is a major pathway in the catabolism and elimination of numerous endo- and xenobiotics.

2024年12月10日 · This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases.

Title: UGT1A1 and UGT1A9 Are Responsible for Phase II Metabolism of Tectorigenin and Irigenin In Vitro. Genetic variants in CYP2A6 and UGT1A9 genes associated with urinary nicotine metabolites in young Mexican smokers.

Results: We confirmed the presence of the -109 to -98 T10 polymorphism and found ten novel SNPs that generated a diversity of haplotypes in two independent populations. In a panel of 48 human liver microsomes, the UGT1A9 expression varied by 17-fold and was significantly correlated with SNPs -275, -331/-440, -665 and -2152.

2022年12月23日 · 由位于染色体2q37上的UGT1A9基因编码的尿苷二磷酸葡萄糖醛酸转移酶，由530个氨基酸组成。 属UGT1A亚家族。