
Get to know a gene: UGT1A4 - GeneSight
2017年7月14日 · What is UGT1A4? The UGT1A4 gene encodes an enzyme of the glucuronidation pathway, a phase II metabolism process that transforms small lipophilic molecules into water-soluble excretable metabolites.
UGT1A4 - Wikipedia
UDP-glucuronosyltransferase 1-4 is an enzyme that in humans is encoded by the UGT1A4 gene. [5][6][7] This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites.
UGT1A4 Gene - GeneCards | UD14 Protein | UD14 Antibody
2024年12月25日 · UGT1A4 (UDP Glucuronosyltransferase Family 1 Member A4) is a Protein Coding gene. Diseases associated with UGT1A4 include Crigler-Najjar Syndrome, Type I and Bilirubin Metabolic Disorder. Among its related pathways are Metapathway biotransformation Phase I and II and Drug ADME.
A pharmacogenetics study of the human glucuronosyltransferase UGT1A4
The main objective of this study was 1) to screen the UGT1A4 gene for polymorphisms in the promoter and coding region, from −4962bp relative to the transcription start site to 2000bp after the first exon, and, 2) to establish their potential effect on UGT1A4 enzymatic function and expression in vitro.
UGT1A4 Gene: Function, Polymorphisms, and Clinical Significance
The UGT1A4 gene, located on chromosome 2q37.3, encodes a member of the UDP-glucuronosyltransferase (UGT) family of proteins. UGTs play a crucial role in detoxifying various endogenous and exogenous compounds by catalyzing the transfer of glucuronic acid from UDP-glucuronic acid to these substrates.
UGT1A4 UDP glucuronosyltransferase family 1 member A4
2025年2月19日 · Chinese patients with A/A or G/A genotype in the promoter region of bilirubin glucuronoside glucuronosyltransferase (UGT1A4) have a lower 5-year disease-free survival (DFS) rate than those with the wild-type G/G genotype when treated with adjuvant tamoxifen.
UGT1A4 UDP glucuronosyltransferase family 1 member A4 …
2024年12月10日 · UGT1A4*3 encodes significantly increased glucuronidation of olanzapine in patients on maintenance treatment and in recombinant systems. Haslemo T, et al. Clin Pharmacol Ther, 2012 Aug. PMID 22713701. What's a GeneRIF? Impact of UGT1A4 and UGT2B7 polymorphisms on lamotrigine plasma concentration in patients with bipolar disorder.
UGT1A4 - an overview | ScienceDirect Topics
UGT1A4 is responsible for lamotrigine glucuronidation. During pregnancy, lamotrigine levels fall faster than in non-pregnant patients, which may be due to the activity of placental UGT1A4 [122]. One compound that has gained significant attention due …
UGT1A4 UDP glucuronosyltransferase family 1 member A4
2024年1月25日 · This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases.
Functional analysis of UGT1A4(P24T) and UGT1A4(L48V) variant enzymes
Results: UGT1A4 (L48V) had higher enzyme efficiency (CL (int)) compared with wild-type UGT1A4 on DHT glucuronidation; UGT1A4 (P24T) and UGT1A4 (L48V) had lower CL (int) than wild-type UGT1A4 for t-AND and LTG glucuronidation.