2017年7月14日 · What is UGT1A4? The UGT1A4 gene encodes an enzyme of the glucuronidation pathway, a phase II metabolism process that transforms small lipophilic molecules into water-soluble excretable metabolites.

UDP-glucuronosyltransferase 1-4 is an enzyme that in humans is encoded by the UGT1A4 gene. [5][6][7] This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites.

2024年12月25日 · UGT1A4 (UDP Glucuronosyltransferase Family 1 Member A4) is a Protein Coding gene. Diseases associated with UGT1A4 include Crigler-Najjar Syndrome, Type I and Bilirubin Metabolic Disorder. Among its related pathways are Metapathway biotransformation Phase I and II and Drug ADME.

The main objective of this study was 1) to screen the UGT1A4 gene for polymorphisms in the promoter and coding region, from −4962bp relative to the transcription start site to 2000bp after the first exon, and, 2) to establish their potential effect on UGT1A4 enzymatic function and expression in vitro.

The UGT1A4 gene, located on chromosome 2q37.3, encodes a member of the UDP-glucuronosyltransferase (UGT) family of proteins. UGTs play a crucial role in detoxifying various endogenous and exogenous compounds by catalyzing the transfer of glucuronic acid from UDP-glucuronic acid to these substrates.

2025年2月19日 · Chinese patients with A/A or G/A genotype in the promoter region of bilirubin glucuronoside glucuronosyltransferase (UGT1A4) have a lower 5-year disease-free survival (DFS) rate than those with the wild-type G/G genotype when treated with adjuvant tamoxifen.

2024年12月10日 · UGT1A4*3 encodes significantly increased glucuronidation of olanzapine in patients on maintenance treatment and in recombinant systems. Haslemo T, et al. Clin Pharmacol Ther, 2012 Aug. PMID 22713701. What's a GeneRIF? Impact of UGT1A4 and UGT2B7 polymorphisms on lamotrigine plasma concentration in patients with bipolar disorder.

UGT1A4 is responsible for lamotrigine glucuronidation. During pregnancy, lamotrigine levels fall faster than in non-pregnant patients, which may be due to the activity of placental UGT1A4 [122]. One compound that has gained significant attention due …

2024年1月25日 · This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases.

Results: UGT1A4 (L48V) had higher enzyme efficiency (CL (int)) compared with wild-type UGT1A4 on DHT glucuronidation; UGT1A4 (P24T) and UGT1A4 (L48V) had lower CL (int) than wild-type UGT1A4 for t-AND and LTG glucuronidation.