2021年2月26日 · Umbilical cord-derived mesenchymal stem/stromal cells (UC-MSCs) emerge as a perspective for therapeutic use in immune and inflammatory diseases. Indeed, immunomodulatory and anti-inflammatory properties, associated to fewer ethical, availability, and safety issues, position UC-MSCs as a promising active substance to develop medicinal products.

Human umbilical cord (UC) is a promising source of mesenchymal stem cells (MSCs). Apart from their prominent advantages, such as a painless collection procedure and faster self-renewal, UC-MSCs have shown the ability to differentiate into three germ ...

Several MSC-based medicines (BM-, AT-, or UC-MSCs) have been granted MA, which remain limited to certain countries. In Europe, only one MA was granted, Alofisel®, an allogeneic AT-MSC-based CT product, to treat complex anal fistulas in Crohn’s disease.

2024年4月23日 · Umbilical cord-derived mesenchymal stem cells (UC-MSCs) present a promising alternative, capitalizing on their low immunogenicity and potent immunomodulatory effects...

Commonly, MSC isolation from UC is divided into four main sections: the Wharton’s Jelly (WJ), the perivascular area (PV), the sub-amnion (SA), and the Amnion membrane (AM). WJ-MSCs are isolated by dissecting out the arteries and extracting the WJ from the UC using knife or forceps.

Umbilical cord mesenchymal stem cells (UC-MSCs) are multifunctional stem cells and are found in the neonatal umbilical cord tissue. They proliferate continuously and differentiate into one or more cell types under specific conditions [84].

2021年11月13日 · Umbilical cord-derived mesenchymal stromal cells (UC-MSCs) revealed their key role in immune regulation, offering promising therapeutic perspectives for immune and inflammatory diseases.

2021年5月2日 · Umbilical cord mesenchymal stem cells (UC-MSCs) are a class of multifunctional stem cells isolated and cultured from umbilical cord. They possessed the characteristics of highly self-renewal, multi-directional differentiation potential and low immunogenicity.

2016年12月5日 · We found that UC-MSCs suppressed monocyte differentiation into DCs and instructed monocytes towards other cell types, with clear decreases in the expression of co-stimulatory molecules,...

2020年8月3日 · UC-MSCs can effectively improve the renal function, inhibit inflammation and fibrosis, and prevent its progression in a model of diabetes-induced chronic renal injury, indicating that UC-MSCs could be a promising treatment strategy for DN.