This gene encodes the U2AF large subunit, which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly.

Oct 19, 2014 · Through genome-wide analysis of U2AF-RNA interactions, we report that U2AF has the capacity to directly define ~88% of functional 3′ splice sites in the human genome, but numerous U2AF...

含有rs结构域的主要剪接因子包括u2af亚基以及u1 snrnp复合物中u170k蛋白。在含有rs结构域中最常见的是sr家族蛋白，它的n端含有rrm结构域以及在c端含有rs结构域。 在sr家族蛋白中有一些成员也含有两个rrm结构域。

U2AF是U2 snRNP auxiliary factor即U2 snRNP辅助因子。 这个蛋白质又叫人类淋巴细胞抗原B相关转录本1蛋白(HLA-B-associated transcript 1 protein, BAT1)，这个蛋白有RNA解旋酶活性；

Dec 25, 2024 · U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing.

U2 auxiliary factor (U2AF) complex is a non–small nuclear ribonucleoprotein protein required for binding U2 small nuclear ribonucleoprotein to the pre-mRNA branch site and is involved in the recognition of the 3′ splice site [75].

Sep 21, 2020 · Here, we describe the first crystal structures of wild-type and pathogenic mutant U2AF1 complexed with target RNA, revealing the mechanism of 3´ splice site selection, and how aberrant splicing...

Mar 8, 2016 · How the essential pre-mRNA splicing factor U2AF 65 recognizes the polypyrimidine (Py) signals of the major class of 3′ splice sites in human gene transcripts remains incompletely understood. We...

单个亚基的结合特异性在剪接体组装和功能中起着至关重要的作用。论文第一作者Lena Voithenberg说，“我们研究的被称作U2辅助因子（简写为U2AF）的组装因子在正确识别这些内含子的一端上的剪接位点中发挥关键性作用。” U2AF本身是由两种不同的亚基组成的。

U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing.