- Tumor-associated macrophages (TAMs) are primary immunosuppressive effectors that foster tumor proliferation, angiogenesis, metastasis, and resistance to therapy.www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1556209/…
Linking macrophage metabolism to function in the tumor ... - Nature
2025年2月17日 · Tissue-resident macrophages are highly tuned to integrate tissue niche signals, and multiple factors within the idiosyncratic tumor microenvironment (TME) drive macrophages …
仅显示来自 nature.com 的搜索结果The complex role of tumor-in…
After phagocytosis of cancer cells by macrophages, AIM2, which is activated …
Roles of macrophages in t…
We discuss how macrophages may prime the premetastatic niche to enable the …
Macrophage polarization in the tumor microenvironment: …
2024年8月1日 · Here, we review the latest investigations on factors orchestrating macrophage polarization in the TME, how macrophage polarization affects tumor progression, and the …
The complex role of tumor-infiltrating macrophages - Nature
2022年7月25日 · After phagocytosis of cancer cells by macrophages, AIM2, which is activated by tumor DNA, cleaves cGAS and upregulates PD-L1 and IDO, overriding the anti-tumor function …
Targeting macrophages in cancer immunotherapy: Frontiers and …
2025年1月6日 · In this context, we critically analyze the innovative strategies aimed at transforming macrophages from their M2 (tumor-promoting) to M1 (tumor-suppressing) …
Roles of macrophages in tumor development: a spatiotemporal
2023年7月10日 · We discuss how macrophages may prime the premetastatic niche to enable the growth of a metastasis and then how subsequent metastasis-associated macrophages can …
CD47 blockade reverses resistance to HDAC inhibitor by liberating …
5 天之前 · Similar to the MC38 model, VOR exhibited limited effectiveness in suppressing tumor growth in Mac + nude mice, while the depletion of macrophages drastically sensitized the anti …
The role of tumor-associated macrophages in lung cancer
4 天之前 · These subtypes include M2a, M2b, M2c, and M2d, each associated with different aspects of tumor support. M2a macrophages, driven by IL-4 and IL-13, are primarily involved …
Tumor secretome shapes the immune landscape during cancer …
2025年2月10日 · CCL2 is instrumental in attracting tumor-associated macrophages (TAMs) that adopt a pro-tumorigenic phenotype, supporting cancer cell survival, enhancing tumor cell …
m6A RNA methylation: a pivotal regulator of tumor immunity and …
1 天前 · The role of m6A modification in tumor innate immunity. Innate immunity is a non-specific defense mechanism that develops during the organism’s growth, playing essential roles such …
Targeted delivery of CCL3 reprograms macrophage antigen
6 天之前 · The immunosuppressive tumor immune microenvironment (TIME), characterized by low immune cell infiltration and exhaustion, limits immunotherapy efficacy. ... promoting …
