Tumour heterogeneity and resistance to cancer therapies
2017年11月8日 · In this Review, the authors describe the role of tumour heterogeneity in the development of acquired resistance, potential treatment strategies that take into account the …
What Is Tumor Heterogeneity? - Memorial Sloan Kettering Cancer Center
2014年7月2日 · Understanding tumor heterogeneity may be the next big quest in cancer science, as differences between cells within a tumor can have important consequences for how …
Tumour heterogeneity - Wikipedia
Tumour heterogeneity describes the observation that different tumour cells can show distinct morphological and phenotypic profiles, including cellular morphology, gene expression, …
Tumor heterogeneity: causes and consequences - PMC
Human cancers frequently display substantial intra-tumor heterogeneity in virtually all distinguishable phenotypic features, such as cellular morphology, gene expression (including …
Tumor Heterogeneity: A Great Barrier in the Age of Cancer …
We will discuss how tumor heterogeneity causes resistance to various treatments and review the strategies currently being employed to overcome this challenging clinical hurdle. Finally, we …
Tumor heterogeneity: Cancer Cell - Cell Press
2021年8月9日 · Tumors are spatially organized heterogeneous ecosystems: at the cellular level, they contain both cancer and stromal cell populations; at the genetic level, they are composed …
Tumour Cell Heterogeneity - PMC
In this mini-review, we summarise the extent of intra-tumour heterogeneity (ITH) across human malignancies, review the mechanisms that are responsible for generating and maintaining ITH, …
Understanding the Cause and Consequence of Tumor Heterogeneity …
2020年2月13日 · Here we discuss the implications of how molecularly targeted therapies in solid malignancies that promote limited cancer cell death may in fact make tumors more …
Tumour heterogeneity and cancer cell plasticity - Nature
2013年9月18日 · Phenotypic and functional heterogeneity arise among cancer cells within the same tumour as a consequence of genetic change, environmental differences and reversible …
Tumor heterogeneity: causes and consequences - PubMed
We review experimental evidence for the existence of both intra-tumor clonal heterogeneity as well as frequent evolutionary divergence between primary tumors and metastatic outgrowths. …