Tumor-associated macrophages (TAMs) are a class of immune cells present in high numbers in the microenvironment of solid tumors. They are heavily involved in cancer-related inflammation.

Tumor-associated macrophages (TAMs) represent one of the main tumor-infiltrating immune cell types and are generally categorized into either of two functionally contrasting subtypes, namely classical activated M1 macrophages and alternatively activated M2 macrophages.

2023年2月15日 · Clinical correlative data and a plethora of preclinical studies in mouse models of cancers have shown that tumour-associated macrophages (TAMs) play a cancer-promoting role. Within the...

2023年7月10日 · Tumor-associated macrophages favor tumor development through different functions. TAMs have various roles in tumorigenesis and as such, interact closely with cancer cells and the TME.

2020年12月3日 · Tumor-associated macrophages (TAMs) represent one of the main tumor-infiltrating immune cell types and are generally categorized into either of two functionally contrasting subtypes, namely classical activated M1 macrophages and …

Tumor-associated macrophages (TAMs) occupying more than 50% of tumor-infiltrating cells can be broadly classified as M1-like, pro-inflammatory subtype and M2-like, immunosuppressive subtype (3, 7).

Tumor-associated macrophages (TAMs) as a major part in the tumor environment (TME) are associated with the progression of tumor. This review summarizes the roles TAMs play and some TAM targeting strategies.

2022年7月25日 · Tumor-associated macrophages (TAMs) represent the most abundant innate immune population in the tumor microenvironment (TME). Macrophages are professional phagocytic cells of the...

However, tumor-associated macrophages (TAMs) express cytokines and chemokines that can suppress antitumor immunity and promote tumor progression. Preclinical studies have identified crucial pathways regulating the recruitment, polarization, and …

By instilling temporal dynamism into the more static classic view of tumor-associated macrophage biology, we propose a new framework to better contextualize their significance in the inflammatory processes that precede and result from the onset of cancer and shape its evolution.