2024年12月25日 · TSPAN4 (Tetraspanin 4) is a Protein Coding gene. Diseases associated with TSPAN4 include Paralytic Poliomyelitis and Soft Palate Cancer. Gene Ontology (GO) annotations related to this gene include integrin binding and antigen binding. An …

2023年2月23日 · Among them, tetraspanin 4 (TSPAN4) was found to be the most effective 14. Along with the crucial function of TSPANs in migrasome formation, it was further theoretically suggested that biophysical...

2022年6月2日 · Functionally, Tetraspanin 4 helps cells mitigate damage caused by laser, detergent, pyroptosis and natural killer cells. We propose that assembly of Tetraspanin …

Prominent members of the TSPAN family are tetraspanin 4 (TSPAN4) and CD9, whose crucial intracellular functions have been newly revealed. TSPAN4 has been shown to regulate formation of migrasomes, the recently discovered cell organelles playing essential roles in cell-cell signaling, lateral transfer of messenger RNA and proteins, transport of ...

Gene ID: 7106, updated on 8-Feb-2025. The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains.

2023年1月6日 · TSPAN4 expression differs significantly in immune subtypes of cancers, which can be a diagnostic and prognostic target of cancers due to the high accuracy.

2024年8月16日 · Here, we demonstrate that TSPAN4 is highly expressed in gliomas and correlates with tumor progression and poor prognosis. TSPAN4 knockdown attenuates tumorigenicity of GBM both in vitro and in vivo. Furthermore, TSPAN4 directly interacts with EGFR and is required for EGFR stability.

2024年11月27日 · Title: Identification of TSPAN4 as Novel Histamine H(4) Receptor Interactor. TM4SF4/il-TMP has the potential to be biomarker in a hepatocellular carcinoma and plays a crucial role in promotion of cancer cell proliferation

2024年12月11日 · TSPAN4, a key regulator of migrasome formation, is a valuable marker for visualizing these organelles. However, its role in cancer remains unclear. Methods: We analyzed TSPAN4 expression and its prognostic significance across multiple cancers using TCGA Pan-Cancer (PANCAN), and TCGA TARGET GTEx datasets.

Human tetraspanin transmembrane 4 superfamily member 4 or intestinal and liver tetraspan membrane protein is overexpressed in hepatocellular carcinoma and accelerates tumor cell growth. TSPAN4 and migrasomes in atherosclerosis regression correlated to myocardial infarction and pan-cancer progression.