
TrkB Truncated Isoform Receptors as Transducers and …
(A) Schematic representation of the genomic structure of the murine TrkB gene. Exons are shown as boxes and introns are shown as lines. White and black stars indicate the start and stop …
TrkB transmembrane domain: bridging structural understanding …
2024年3月2日 · TrkB (neuronal receptor tyrosine kinase-2, NTRK2) is the receptor for brain-derived neurotrophic factor (BDNF) and is a critical regulator of activity-dependent neuronal …
Regulation of BDNF-TrkB Signaling and Potential Therapeutic …
Brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase receptor type B (TrkB) are widely distributed in multiple regions of the human brain. Specifically, …
The trkB Tyrosine Protein Kinase Is a Receptor for Brain-Derived ...
Summary. trkB is a tyrosine protein kinase gene highly related to trk, a proto-oncogene that encodes a receptor for nerve growth factor (NGF) and neurotrophin-3 (NT-3).trkB expression …
TrkB signalling pathways in LTP and learning - Nature
In recent years, a role has been proposed for the neurotrophin receptor tyrosine kinase TrkB in synaptic plasticity, learning and memory. Liliana Minichiello discusses the signalling pathways ...
TrkB/BDNF signaling pathway and its small molecular agonists in …
2024年1月1日 · As one of the most prevalent neurotrophic factors in the central nervous system (CNS), brain-derived neurotrophic factor (BDNF) plays a significant role in CNS injury by …
Tropomyosin receptor kinase B (TrkB) signalling: targeted therapy …
Tropomyosin receptor kinase B (TrkB), a transmembrane receptor protein, has been found to play a pivotal role in neural development. This protein is encoded by the neurotrophic receptor …
TrkB/BDNF signaling pathway and its small molecular agonists in …
2024年1月1日 · Mature neurotrophic factors primarily function as non-covalently linked homodimers, such as NT-3/NT-3. However, some neurotrophic factors can also form …
TrkB transmembrane domain: bridging structural understanding …
2024年5月1日 · TrkB is widely expressed in the developing and adult brain. Indeed, essentially all the neurons in the central nervous system express TrkB [7, 8], and glial cells express TrkB.T1, …
Are TrkB receptor agonists the right tool to fulfill the promises for …
BDNF-mediated effects on neuronal structure and function. (A) BDNF and proBDNF are released at postsynaptic sites. BDNF binds TrkB with high affinity to induce its dimerization and …