(A) Schematic representation of the genomic structure of the murine TrkB gene. Exons are shown as boxes and introns are shown as lines. White and black stars indicate the start and stop condons, respectively. Color of exons indicate the domains of the TrkB protein isoforms shown in panel (B).Gray boxes indicate the 3′ untranslated region (UTR) of the TrkB transcripts.

2024年3月2日 · TrkB (neuronal receptor tyrosine kinase-2, NTRK2) is the receptor for brain-derived neurotrophic factor (BDNF) and is a critical regulator of activity-dependent neuronal plasticity. The past few years have witnessed an increasing understanding of the structure and function of TrkB, including its transmembrane domain (TMD). TrkB interacts with membrane …

Brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase receptor type B (TrkB) are widely distributed in multiple regions of the human brain. Specifically, BDNF/TrkB is highly expressed and activated in the dopaminergic ...

Summary. trkB is a tyrosine protein kinase gene highly related to trk, a proto-oncogene that encodes a receptor for nerve growth factor (NGF) and neurotrophin-3 (NT-3).trkB expression is confined to structures of the central and peripheral nervous systems, suggesting it also encodes a receptor for neurotrophic factors.Here we show that brain-derived neurotrophic factor (BDNF) …

In recent years, a role has been proposed for the neurotrophin receptor tyrosine kinase TrkB in synaptic plasticity, learning and memory. Liliana Minichiello discusses the signalling pathways ...

2024年1月1日 · As one of the most prevalent neurotrophic factors in the central nervous system (CNS), brain-derived neurotrophic factor (BDNF) plays a significant role in CNS injury by binding to its specific receptor Tropomyosin-related kinase receptor B (TrkB). The BDNF/TrkB signaling pathway is crucial for neur …

Tropomyosin receptor kinase B (TrkB), a transmembrane receptor protein, has been found to play a pivotal role in neural development. This protein is encoded by the neurotrophic receptor tyrosine kinase 2 (NTRK2) gene, and its abnormal activation caused by NTRK2 overexpression or fusion can contribute to tumour initiation, progression, and resistance to therapeutics in multiple types …

2024年1月1日 · Mature neurotrophic factors primarily function as non-covalently linked homodimers, such as NT-3/NT-3. However, some neurotrophic factors can also form heterodimers with other neurotrophic factors, for instance, known heterodimers like NT-3/BDNF and NT-4/BDNF, which play a role in neuronal protection [8].Neurotrophic factors exert …

2024年5月1日 · TrkB is widely expressed in the developing and adult brain. Indeed, essentially all the neurons in the central nervous system express TrkB [7, 8], and glial cells express TrkB.T1, a splice variant of TrkB that shares the ECD and the TMD of the full-length TrkB but lacks the intracellular tyrosine kinase domain (KD) [4].Subcellularly, most of the full-length TrkB is …

BDNF-mediated effects on neuronal structure and function. (A) BDNF and proBDNF are released at postsynaptic sites. BDNF binds TrkB with high affinity to induce its dimerization and phosphorylation at tyrosine residues in the cytoplasmatic domain, which serves as a docking site for several downstream signaling pathways.