(A) Schematic representation of the genomic structure of the murine TrkB gene. Exons are shown as boxes and introns are shown as lines. White and black stars indicate the start and stop …

2024年3月2日 · TrkB (neuronal receptor tyrosine kinase-2, NTRK2) is the receptor for brain-derived neurotrophic factor (BDNF) and is a critical regulator of activity-dependent neuronal …

Brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase receptor type B (TrkB) are widely distributed in multiple regions of the human brain. Specifically, …

Summary. trkB is a tyrosine protein kinase gene highly related to trk, a proto-oncogene that encodes a receptor for nerve growth factor (NGF) and neurotrophin-3 (NT-3).trkB expression …

In recent years, a role has been proposed for the neurotrophin receptor tyrosine kinase TrkB in synaptic plasticity, learning and memory. Liliana Minichiello discusses the signalling pathways ...

2024年1月1日 · As one of the most prevalent neurotrophic factors in the central nervous system (CNS), brain-derived neurotrophic factor (BDNF) plays a significant role in CNS injury by …

Tropomyosin receptor kinase B (TrkB), a transmembrane receptor protein, has been found to play a pivotal role in neural development. This protein is encoded by the neurotrophic receptor …

2024年1月1日 · Mature neurotrophic factors primarily function as non-covalently linked homodimers, such as NT-3/NT-3. However, some neurotrophic factors can also form …

2024年5月1日 · TrkB is widely expressed in the developing and adult brain. Indeed, essentially all the neurons in the central nervous system express TrkB [7, 8], and glial cells express TrkB.T1, …

BDNF-mediated effects on neuronal structure and function. (A) BDNF and proBDNF are released at postsynaptic sites. BDNF binds TrkB with high affinity to induce its dimerization and …