Migraine is one of the most severe and debilitating brain disorders. Most scientists accept that it involves activation and sensitization of the trigeminovascular system, which includes the ...

Figure 1. Probable sites of action of triptans and calcitonin gene-related peptide receptor antagonists in the trigeminovascular system. Triptans are thought to have actions at 5-HT 1B …

Sidebar Key Issues. Migraine is a severe and debilitating disorder of the brain. It is thought to involve activation of both peripheral and central aspects of the trigeminovascular system.

A further option is the use of 5-HT 1B/1D receptor agonists, which inhibit trigeminovascular neurogenic inflammation. In a double-blind, placebo-controlled study of 24 patients with …

Microvascular decompression of the trigeminal nerve root entry zone is the one procedure that uniquely addresses the presumed underlying pathology of symptomatic neurovascular …