TOPBP1 primarily regulates the DNA damage repair response through its ability to activate the damage response kinase, ataxia-telangiectasia mutated and RAD3-related (ATR). It also plays a critical role in DNA replication initiation and regulation of the cell cycle.

2024年12月25日 · TOPBP1 (DNA Topoisomerase II Binding Protein 1) is a Protein Coding gene. Diseases associated with TOPBP1 include Byssinosis and Ataxia-Telangiectasia. Among its related pathways are Homologous DNA Pairing and Strand Exchange and HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA).

TopBP1（DNA topoisomerase 2 binding protein 1）具有刺激ATR激酶活性的ATR激活域，激活域的失活突变对哺乳动物细胞是致命的。 另一种ATR激活蛋白 ETAA1 含有与TopBP1类似的ATR激活域，但它可通过直接与RPA结合而被募集，可能负责不同类型的损伤。

2025年2月9日 · TopBP1 is likely to be involved in hereditary predisposition to breast and/or ovarian cancer; findings show TopBP1 interacts with p53 hot spot mutants and NF-YA and promotes mutant p53 and p300 recruitment to NF-Y target gene promoters; TopBP1 mediates mutant p53 gain of function in cancer

Human TopBP1 contains nine BRCT domains and functions in DNA replication initiation, checkpoint signalling, DNA repair and influences transcriptional control. TopBP1 and its homologues have been the subject of numerous scientific publications since the last comprehensive review in 2005, emerging as …

该基因编码与拓扑异构酶 II β 的 C 末端区域相互作用的结合蛋白。 这种相互作用表明这种蛋白质通过 DNA 链的瞬时断裂在拓扑异构酶 II β 的催化反应中起支持作用。 [RefSeq 提供，2008 年 7 月] This gene encodes a binding protein which interacts with the C-terminal region of Topoisomerase II beta.

2023年10月31日 · Based on this, we conducted a large-scale molecular docking screening to identify a small-molecule inhibitor that specifically targets the BRCT7/8 domains of TopBP1, which we have named 5D4. Our studies show that 5D4 inhibits TopBP1 interactions with E2F1, mutant p53, and Cancerous Inhibitor of Protein Phosphatase 2A.

2014年10月1日 · TopBP1 and homologues (TopBP1-family) are all ‘scaffold’ or ‘hub’ proteins that are able to make numerous protein–protein interactions through their constituent BRCT domains. BRCT domains are often found in pairs, and the interactions that they make are generally phospho-specific.

2025年2月7日 · DNA topoisomerase II-binding protein 1 (TOPBP1) plays a supportive role in regulating the DDR pathway, and its overexpression has been linked to the tumorigenesis of various cancers. This study investigated the biological role of TOPBP1 in PDAC pathogenesis and evaluated its clinical relevance in guiding treatment regimens.

2016年2月1日 · We show that TOPBP1 acts in homologous recombination (HR) repair, impacts olaparib response, and exhibits aberrant patterns in subsets of human ovarian carcinomas. TOPBP1 depletion abrogated RAD51 loading to chromatin and formation of RAD51 foci, but without affecting the upstream HR steps of DNA end resection and RPA loading.