TOP2B - Wikipedia
DNA topoisomerase 2-beta is an enzyme that in humans is encoded by the TOP2B gene. [5][6] This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic …
Untangling the roles of TOP2A and TOP2B in transcription and …
Nov 2, 2022 · Type II topoisomerases (TOP2) are conserved regulators of chromatin topology that catalyze reversible DNA double-strand breaks (DSBs) and are essential for maintaining …
TOP2B Gene - GeneCards | TOP2B Protein | TOP2B Antibody
Dec 25, 2024 · TOP2B (DNA Topoisomerase II Beta) is a Protein Coding gene. Diseases associated with TOP2B include B-Cell Immunodeficiency, Distal Limb Anomalies, And …
Untangling the roles of TOP2A and TOP2B in transcription and …
Nov 4, 2022 · Type II topoisomerases (TOP2) are conserved regulators of chromatin topology that catalyze reversible DNA double-strand breaks (DSBs) and are essential for maintaining …
DNA 拓扑异构酶 II β（TOP2B）基因 | MCE - MCE-生物活性 ...
该基因编码一种 DNA 拓扑异构酶，一种在转录过程中控制和改变 DNA 拓扑状态的酶。 这种核酶参与染色体浓缩、染色单体分离以及 DNA 转录和复制过程中发生的扭转应力的缓解等过程。 …
TOP2B DNA topoisomerase II beta [ (human)] - National Center …
TOP2B is positioned to solve topological problems at diverse cis-regulatory elements and its occupancy is a highly ordered and prevalent feature of CTCF/cohesin binding sites that flank …
TOP2B: The First Thirty Years - PMC - National Center for …
Sep 14, 2018 · In 1987 the first report of a second type II isoform in mammalians was published by Fred Drake’s group at Smith Kline French (SKF); this isoform was called DNA …
Mapping catalytically engaged TOP2B in neurons reveals the …
Feb 27, 2024 · We trapped catalytically engaged topoisomerase IIβ (TOP2B) in covalent DNA cleavage complexes (TOP2Bccs) and mapped their positions genome-wide in cultured mouse …
Nature Genetics | 内源性DNA双链断裂的元凶——Pol II的停顿与释 …
研究人员通过检测经典DDR通路中的 γ-H2AX信号，发现不同于外源诱导的DSBs，内源产生的DSBs并不激活DDR通路。 从修复方式来看， 外源诱导的DSBs既能够通过HR途径也能够通 …
解开 TOP2A 和 TOP2B 在转录和癌症中的作用,Science Advances
Nov 2, 2022 · II 型拓扑异构酶 (TOP2) 是染色质拓扑结构的保守调节因子，可催化可逆的 DNA 双链断裂 (DSB)，对于在转录、复制和细胞分裂等多种动态过程中维持基因组完整性至关重要。 …