DNA topoisomerase 2-beta is an enzyme that in humans is encoded by the TOP2B gene. [5][6] This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic …

2024年12月25日 · TOP2B (DNA Topoisomerase II Beta) is a Protein Coding gene. Diseases associated with TOP2B include B-Cell Immunodeficiency, Distal Limb Anomalies, And …

2022年11月2日 · Type II topoisomerases (TOP2) are conserved regulators of chromatin topology that catalyze reversible DNA double-strand breaks (DSBs) and are essential for maintaining …

Topoisomerase IIβ was first reported in 1987. Here we review the research on DNA topoisomerase IIβ over the 30 years since its discovery. 1. Discovery of DNA Topoisomerase …

TOP2B is positioned to solve topological problems at diverse cis-regulatory elements and its occupancy is a highly ordered and prevalent feature of CTCF/cohesin binding sites that flank …

2024年2月27日 · We trapped catalytically engaged topoisomerase IIβ (TOP2B) in covalent DNA cleavage complexes (TOP2Bccs) and mapped their positions genome-wide in cultured mouse …

This review will focus on one of the two mammalian type II DNA topoisomerase enzymes, DNA topoisomerase II beta (TOP2B), that have been implicated in correct execution of …

The TOP2B gene encodes a type II topoisomerase, an enzyme that generates transient DNA double-strand breaks to relieve topological stress during DNA replication and transcription …

2019年8月13日 · TOP2B encodes a type II topoisomerase, an essential gene required to alleviate topological stress during DNA replication and gene transcription, with no previously known role …

2016年8月31日 · Type II DNA topoisomerases (TOP2) regulate DNA topology by generating transient double stranded breaks during replication and transcription. Topoisomerase II beta …