2024年12月25日 · TOMM20 (Translocase Of Outer Mitochondrial Membrane 20) is a Protein Coding gene. Diseases associated with TOMM20 include Parkinson Disease 25, Autosomal Recessive Early-Onset, With Impaired Intellectual Development and Parkinson Disease 2, Autosomal Recessive Juvenile .

Translocase of outer mitochondrial membrane 20 (TOMM20) plays an essential role as a receptor for proteins targeted to mitochondria. TOMM20 was shown to be overexpressed in various cancers. However, the oncological function and therapeutic potential for TOMM20 in cancer remains largely unexplored.

TOMM20 protein is highly expressed in both anaplastic thyroid cancer and papillary thyroid cancer compared to non-cancerous thyroid tissue. Tom20 was ubiquitously distributed in the organ of Corti, allowing well-delineated visualization of inner and outer hair cells.

Alternatively, immunocytochemical methods to label cells using antibodies against mitochondrial proteins [such as stress-70 protein (HSPA13), GRP75/HSPA9, or mitochondrial import receptor subunit TOM20 (TOMM20)] could be used to assess mitochondrial morphology and mass. In both cases, a relatively inert cytosolic dye such as calcein (in living ...

TOMM20 is a member of the mitochondrial translocase of the outer membrane, which functions to shuttle mitochondrial-targeted proteins to the mitochondrial matrix (Omura, 1998) and has been implicated in pathophysiology of Parkinson's disease (Franco-Iborra et …

2025年1月5日 · Translocase of the outer mitochondrial membrane complex subunit 20 (TOMM20) facilitates cancer aggressiveness and therapeutic resistance in chondrosarcoma. Roche ME, et al. Biochim Biophys Acta Mol Basis Dis, 2020 Dec 1. PMID 32920118, Free PMC Article.

2025年2月9日 · Translocase of the outer mitochondrial membrane complex subunit 20 (TOMM20) facilitates cancer aggressiveness and therapeutic resistance in chondrosarcoma. Roche ME, Lin Z, Whitaker-Menezes D, Zhan T, Szuhai K, Bovee JVMG, Abraham JA, Jiang W, Martinez-Outschoorn U, Basu-Mallick ARoche ME, et al. Biochim Biophys Acta Mol Basis Dis, 2020 Dec 1.

2025年3月6日 · To our knowledge, this is the first report demonstrating that TOMM20, a mitochondrial outer translocase protein, stabilizes AR protein and enhances its transcriptional activity, while its knockdown promotes AR degradation through the SKP2-mediated ubiquitin-proteasome pathway.

2025年2月25日 · Translocase of outer mitochondrial membrane receptor 20 (TOMM20) is a mitochondrial receptor protein associated with cancer aggressiveness in many cancer subtypes, but the mechanisms remain poorly understood.

2025年3月6日 · Surprisingly, our study identified TOMM20, a mitochondrial outer membrane protein, as a potential molecular chaperone with similar roles to HSP90/HSP70. We found that TOMM20 expression is...