The TNNT1 gene is located at 19q13.4 in the human chromosomal genome, encoding the slow twitch skeletal muscle isoform of troponin T (ssTnT). ssTnT is an ~32-kDa protein consisting of 262 amino acids (including the first methionine) with an isoelectric point (pI) of 5.95.

2024年12月25日 · TNNT1 (Troponin T1, Slow Skeletal Type) is a Protein Coding gene. Diseases associated with TNNT1 include Nemaline Myopathy 5A, Autosomal Recessive, Severe Infantile and Nemaline Myopathy 5B, Autosomal Recessive, Childhood-Onset .

Three homologous genes have evolved in vertebrates to encode three muscle type-specific TnT isoforms: TNNT1 for slow skeletal muscle TnT, TNNT2 for cardiac muscle TnT, and TNNT3 for fast skeletal muscle TnT.

In the present study, we found that TNNT1 was significantly up‐regulated in CRC samples and cell lines. The up‐regulation of TNNT1 was also associated with several clinicopathologic features, and its high expression was correlated with an unfavorable prognosis of the patients.

Clinical phenotype and loss of the slow skeletal muscle troponin T in three new patients with recessive TNNT1 nemaline myopathy. TNNT1, negatively regulated by miR-873, promotes the progression of colorectal cancer.

2016年5月10日 · Three homologous genes have evolved in vertebrates to encode three muscle type-specific TnT isoforms: TNNT1 for slow skeletal muscle TnT, TNNT2 for cardiac muscle TnT, and TNNT3 for fast skeletal muscle TnT.

2016年5月10日 · Three homologous genes have evolved in vertebrates to encode three muscle type-specific TnT isoforms: TNNT1 for slow skeletal muscle TnT, TNNT2 for cardiac muscle TnT, and TNNT3 for fast skeletal muscle TnT.

2024年10月10日 · Clinical phenotype and loss of the slow skeletal muscle troponin T in three new patients with recessive TNNT1 nemaline myopathy. TNNT1, a prognostic indicator in colon adenocarcinoma, regulates cell behaviors and mediates EMT process. TNNT1 facilitates proliferation of breast cancer cells by promoting G (1)/S phase transition.

2023年5月22日 · HGNC Approved Gene Symbol: TNNT1. The TNNT1 gene encodes the slow skeletal muscle troponin. The sarcomere, the contractile element in muscle, including the myocardium, is constituted by 7 major proteins and several …

2025年2月8日 · Data show that cardiac expression of slow skeletal troponin T (Tnnt1) strictly depends on the physical interaction between GATA4-FOG2 in the myocardium of both atria and ventricles. This gene encodes the slow skeletal tropomyosin-binding subunit of the troponin complex and plays an essential role in the regulation of striated muscle contraction.