The tumor necrosis factor receptor superfamily (TNFRSF) is a protein superfamily of cytokine receptors characterized by the ability to bind tumor necrosis factors (TNFs) via an extracellular cysteine -rich domain. [2][3] With the exception of nerve growth factor (NGF), all TNFs are homologous to the archetypal TNF-alpha. [4]

Receptors in the TNFSF family activate diverse cellular functions, from production of type 1 interferons to the modulation of survival of antigen-activated T cells. Here, we focus attention on the subset of TNF superfamily receptors encoded on the immune response locus at Chr 1p36.

2019年1月1日 · The tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamilies (TNFSF/TNFRSF) include 19 ligands and 29 receptors that play important roles in the modulation of cellular functions.

The TNFRSF receptors are characterized by the presence of one or more copies of a conserved cysteine-rich domain in the N-terminal part of these molecules (1, 2). According to structural and functional similarities, three subcategories of TNFRSF receptors can be defined.

Tumor necrosis factor (TNF) superfamily pathways regulate cell proliferation, cell death, and morphogenesis. TNF superfamily receptors mediate various cancers and immune-mediated diseases.

Tumor necrosis factor (TNF) superfamily ligands show diverse biological functions, such as the induction of apoptotic cell death or cell survival and proliferation, making them excellent therapeutic targets for cancer and autoimmunity. We review the latest literature on TNF receptor superfamily signaling with a focus on structure-function.

2022年7月5日 · Tumor necrosis factor receptor superfamily (TNFRSF) members such as CD40, OX40 and CD137/4-1BB are expressed on myeloid cells and/or lymphocytes, and they regulate antigen presentation and adaptive immune activities.

2024年10月24日 · Here, we provide an overview of the past and current clinical trials targeting individual TNFSF or TNFRSF members in autoimmune and inflammatory disease and cancer. We describe the range of...

2024年12月25日 · TNFRSF4 (TNF Receptor Superfamily Member 4) is a Protein Coding gene. Diseases associated with TNFRSF4 include Immunodeficiency 16 and Hemolytic Uremic Syndrome, Atypical 6. Among its related pathways are Akt Signaling and TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions.

2013年1月21日 · TNF receptor superfamily (TNFRSF) molecules contain variable numbers of cysteine-rich domains in their ligand-binding extracellular regions (ectodomains).