The tumor necrosis factor receptor superfamily (TNFRSF) is a protein superfamily of cytokine receptors characterized by the ability to bind tumor necrosis factors (TNFs) via an extracellular cysteine -rich domain. [2][3] With the exception of nerve growth factor (NGF), all TNFs are homologous to the archetypal TNF-alpha. [4] .

Tumor Necrosis Factor Receptor (TNFR) refers to a family of membrane proteins that play a crucial role in activating cell death pathways and regulating gene expression for cellular survival and differentiation.

Costimulatory signals initiated by the interaction between the tumor necrosis factor (TNF) ligand and cognate TNF receptor (TNFR) superfamilies promote clonal expansion, differentiation, and survival of antigen-primed CD4 + and CD8 + T cells and have a pivotal role in T-cell-medi …

Jan 25, 2021 · Here we present a biochemical and structural characterisation of the small molecule-stabilised TNF-TNFR1 complex, providing insights into how a distorted TNF trimer can alter signalling...

Aug 1, 2000 · TNF alpha exerts many of its effects by binding, as a trimer, to either a 55 kDa cell membrane receptor termed TNFR-1 or a 75 kDa cell membrane receptor termed TNFR-2. Both these receptors belong to the so-called TNF receptor superfamily. The superfamily includes FAS, CD40, CD27, and RANK.

Here, we review the role of the TNFR2 signaling pathway in tolerance and the equilibrium of T cell responses and its connections with oncogenesis. We analyze recent discoveries concerning the targeting of TNFR2 in cancer, as well as the advantages, limitations, and …

Tumor necrosis factor receptor 1 (TNFR1) is a protein located on the surface of cells that primarily transmits signals by interacting with tumor necrosis factor-α (TNF-α) and participates in biological processes such as inflammation, cell survival, and apoptosis.