TNF receptor superfamily - Wikipedia
The tumor necrosis factor receptor superfamily (TNFRSF) is a protein superfamily of cytokine receptors characterized by the ability to bind tumor necrosis factors (TNFs) via an extracellular …
The TNF-TNFR Family of Co-signal Molecules - PubMed
Costimulatory signals initiated by the interaction between the tumor necrosis factor (TNF) ligand and cognate TNF receptor (TNFR) superfamilies promote clonal expansion, differentiation, …
Tumor Necrosis Factor Receptor - an overview - ScienceDirect
Tumor Necrosis Factor Receptor (TNFR) refers to a family of membrane proteins that play a crucial role in activating cell death pathways and regulating gene expression for cellular …
Structural insights into the disruption of TNF-TNFR1 ... - Nature
2021年1月25日 · Here we present a biochemical and structural characterisation of the small molecule-stabilised TNF-TNFR1 complex, providing insights into how a distorted TNF trimer …
Regulation of tumour necrosis factor signalling: live or let die
2015年5月26日 · This Review focuses on the recent advances that have been made in understanding TNFR signalling and the consequences of its deregulation for cellular survival, …
TNF alpha and the TNF receptor superfamily: structure ...
2000年8月1日 · TNF alpha exerts many of its effects by binding, as a trimer, to either a 55 kDa cell membrane receptor termed TNFR-1 or a 75 kDa cell membrane receptor termed TNFR-2. …
The TNF-α/TNFR2 Pathway: Targeting a Brake to Release the ...
Here, we review the role of the TNFR2 signaling pathway in tolerance and the equilibrium of T cell responses and its connections with oncogenesis. We analyze recent discoveries concerning …