Tumor necrosis factor (TNF), formerly known as TNF-α, is a chemical messenger produced by the immune system that induces inflammation. [5] . TNF is produced primarily by activated macrophages, and induces inflammation by binding to its receptors on other cells. [6] .

2024年12月25日 · This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR.

Tumor necrosis factor alpha (TNF-α) was initially recognized as a factor that causes the necrosis of tumors, but it has been recently identified to have additional important functions as a pathological component of autoimmune diseases. TNF-α binds to two different receptors, which initiate signal transduction pathways.

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2010年1月19日 · Understanding the mechanisms underlying inflammation-mediated metastasis will reveal new therapeutic targets for cancer prevention and treatment. Tumour necrosis factor (TNF)- α is a key...

2000年8月1日 · Tumour Necrosis Factor alpha (TNF alpha), is an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and is responsible for a diverse range of signalling events within cells, leading to necrosis or apoptosis. The protein is also important for resistance to infection and cancers.

Tumor Necrosis Factor Alpha (TNF-α) is a cytokine that acts as an arbitrator of the local tissue environment following injury, and is involved in bone tissue regeneration. It can initiate apoptosis and regulate cell survival and proliferation.