TIMP1 is an inhibitory molecule that regulates matrix metalloproteinases (MMPs), and disintegrin-metalloproteinases (ADAMs and ADAMTSs). [6] In regulating MMPs, TIMP1 plays a crucial …

Dec 25, 2024 · TIMP1 (TIMP Metallopeptidase Inhibitor 1) is a Protein Coding gene. Diseases associated with TIMP1 include Oral Submucous Fibrosis and Conjunctivochalasis . Among its …

TIMP-1 is an activator of MHC-I expression in myeloid dendritic cells with implications for tumor immunogenicity. HLA-B and TIMP1 as hub genes of the ventricular remodeling caused by …

Dec 9, 2016 · Here, we review how the four non-redundant tissue inhibitors of metalloproteinases (TIMPs) regulate the pericellular proteolysis of a vast range of matrix and cell surface proteins, …

TIMPs were originally characterized as inhibitors of matrix metalloproteinases (MMPs), but their range of activities has now been found to be broader as it includes the inhibition of several of …

May 22, 2024 · Primary human and bone-marrow-derived DCs secrete TIMP-1, which notably increases MHC-I expression in classical type 1 dendritic cells (cDC1), especially under …

Sep 23, 2022 · From clinical evidence, TIMP-1 emerges as an important regulator of inflammatory processes. TIMP-1 is detected, at elevated levels, in the blood of patients with an …

Feb 6, 2023 · Unbiased ligand-receptor-capture-screening revealed TIMP-1-interaction with Amyloid Precursor Protein (APP) family members, namely APP and Amyloid Precursor-like …

Dec 10, 2024 · Title: TIMP1 promotes thyroid cancer cell progression through macrophage phenotypic polarization via the PI3K/AKT signaling pathway. TIMP-1 is an activator of MHC-I …

TIMP1 is a member of the TIMP family that regulates the pericellular proteolysis of extracellular matrix (ECM) and cell surface proteins by inhibiting metalloproteinases post-translationally. …