Thy-1 or CD90 (C luster of D ifferentiation 90) is a 25–37 k Da heavily N-glycosylated, glycophosphatidylinositol (GPI) anchored conserved cell surface protein with a single V-like immunoglobulin domain, originally discovered as a thymocyte antigen.

Dec 25, 2024 · THY1 (Thy-1 Cell Surface Antigen) is a Protein Coding gene. Diseases associated with THY1 include Retinal Artery Occlusion and Thymoma . Among its related pathways are Metabolism of proteins and Integrin Pathway .

Sep 15, 2004 · Thy-1 (CD90) is a small GPI-anchored protein that is particularly abundant on the surface of mouse thymocytes and peripheral T cells. T cell proliferation and cytokine synthesis in response to Thy-1 cross-linking by specific mAb suggests a role for Thy-1 …

Official gene symbol, which is typically a short form of the gene name, according to HGNC. Assigned HPA protein class (es) for the encoded protein (s). Number of protein-coding transcripts from the gene as defined by Ensembl.

Dec 17, 2018 · Thy-1 is a prime exemplar of a membrane organizer for this post-genomic era: one little protein, modified with lipids and carbohydrates, that combines with multiple receptors and signaling pathways to fine tune diverse physiological functions. Thy-1 Abundance – …

Feb 25, 2019 · More than 50 years after its original description as a lymphocyte marker (Reif and Allen, 1964), Thy-1 (CD90) remains an enigmatic molecule. It is expressed on the surface of numerous and diverse cell types, and confers varied effects on cell phenotype, depending on context (reviewed in Bradley et al., 2009).

Apr 25, 2019 · Thy-1, via its GPI anchor, modulates Src family kinase and focal adhesion kinase phosphorylation and subcellular localization, and fibroblast migration, in response to thrombospondin-1/hep I. Exp. Cell Res. 312, 3752–3767. doi: 10.1016/j.yexcr.2006.07.029

Oct 17, 2013 · Thy-1 (thymocyte differentiation antigen 1), also known as CD90 (cluster of differentiation 90), is a highly conserved cell surface molecule that can exist in membrane-bound and soluble forms.

Jan 1, 2010 · Thy-1, a versatile modulator of signaling affecting cellular adhesion, proliferation, survival, and cytokine/growth factor responses. Rege TA et al: 17027000: 2006: Thy-1, via its GPI anchor, modulates Src family kinase and focal adhesion kinase phosphorylation and subcellular localization, and fibroblast migration, in response to ...

There are 3 potential isoforms mapped to this entry. There are two major alleles; Thy-1.1 (CD90.1) and Thy-1.2 (CD90.2). Sequence problems. Any medical or genetic information present in this entry is provided for research, educational and informational purposes only.