Site-Specific Conjugation to Cys-Engineered THIOMAB™ …
Antibodies bearing engineered cysteine residues (termed THIOMAB™ antibodies) enable the site-selective attachment of a drug, label or other payload for specific delivery to certain tissues …
A Platform for the Generation of Site-Specific Antibody–Drug …
2020年7月22日 · THIOMAB antibody technol. utilizes cysteine residues engineered onto an antibody to allow for site-specific conjugation. The technol. has enabled the exploration of …
Determination of the decapping efficiency of THIOMAB™ …
2024年12月17日 · The site-specific antibody-drug conjugates (ADCs), particularly those utilizing the engineered cysteine in Fc fragments of mAbs (THIOMAB™ antibodies), have emerged as …
Site-specific conjugation of a cytotoxic drug to an antibody ... - Nature
2008年7月20日 · Our THIOMAB technology resolves the issue of conjugate heterogeneity by directing the attachment of drugs at defined sites and with near-uniform stoichiometry.
Use of a next generation maleimide in combination with THIOMAB ...
Herein we demonstrate that conjugation of a next generation maleimide (NGM) to engineered cysteines in a THIOMAB™ antibody delivers a THIOMAB™ antibody-drug conjugate (TDC) …
Site-specific antibody drug conjugates for cancer therapy - PMC
Keywords: site-specific conjugation, antibody drug conjugate, THIOMAB, internalization, tumor antigen, linker, cytotoxic drug. Introduction. Monoclonal antibodies (mAbs) have long been an …
Engineering THIOMABs for site-specific conjugation of thiol-reactive ...
Recently, we have engineered THIOMABs (antibodies with engineered reactive cysteine residues) for site-specific conjugation and showed that these antibody conjugates display homogeneous …
A homogeneous high-DAR antibody–drug conjugate platform …
Herein, we describe the development of a novel bioconjugation platform combining cysteine-engineered (THIOMAB) antibodies and recombinant XTEN polypeptides for the …
ThioMabs: improving safety abd retaining efficacy of antibody …
2007年5月1日 · We have developed a novel robust biochemical assay (PHESELECTOR) to screen reactive thiols on antibody surface with an objective of utilizing these thiol groups for …
The THIOMAB™ antibody technology platform uses site-directed mutagenesis to incorporate cysteines into the anti-body. Conjugation to a classical maleimide bearing the drug of choice …