The new protein–disulfide bond is introduced via thiol–disulfide exchange reactions between the oxidized PDI and the substrate protein thiols. In the first step, PDI forms a mixed disulfide …

The rapid thiol–disulfide exchange reaction of the PDS group with thiol functional groups has been exploited from the reversible conjugation of therapeutic agents to the fabrication of redox …

2022年7月20日 · Disulfide bonds and free thiol groups in both proteins and smaller organic molecules like glutathione can 'trade places' through a disulfide exchange reaction. This …

The disulfide exchange (also called interchange) process involves attack of the thiol at the disulfide, breaking the -S–S- bond, with subsequent formation of a new mixed disulfide …

The formation of protein mixed disulfides (P-S-S-R) occurs in all biological environments, typically by one of two mechanisms: (i) thiol-disulfide exchange; P-S-S-P + R-SH ↔ P-S-S-R + P-SH or …

2023年10月11日 · We report a rapid cross-linking strategy for the fabrication of polymer hydrogels based on a thiol–disulfide cascade reaction. Specifically, thiolated polymers (e.g., …

2021年1月8日 · Thiol-disulfide exchange, one of the most popular dynamic combinatorial chemistries, usually needs long equilibration times to reach the required equilibrium …

Hence, thiol–disulfide exchange is inhibited at low pH (typically, below 8) where the protonated thiol form is favored relative to the deprotonated thiolate form. (The pK a of a typical thiol …

2021年4月2日 · Unsymmetrical disulfides have been effectively prepared through thiol exchange with symmetrical disulfides employing a simple PdCl 2 /DMSO catalytic system. The given …

In solution, thiol-disulfide exchange occurs when a disulfide (R'SSR") reacts with a dissimilar thiol (RSH), generating the mixed disulfide (R'SSR) with the expulsion of the thiol group with the …