Warburg effect (oncology) - Wikipedia
In oncology, the Warburg effect (/ ˈ v ɑːr b ʊər ɡ /) is the observation that most cancer use aerobic glycolysis for energy generation rather than the mechanisms used by non-cancerous cells. [1]
The Warburg Effect: How Does it Benefit Cancer Cells? - PMC
The Warburg Effect is defined as an increase in the rate of glucose uptake and preferential production of lactate, even in the presence of oxygen. Each of these functions have been hypothesized to be the function of the Warburg Effect.
Glucose Metabolism in Cancer: The Warburg Effect and Beyond
2021年5月21日 · Review Warburg, me and Hexokinase 2: Multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "Warburg Effect", i.e., elevated glycolysis in the presence of oxygen.
Understanding the Warburg Effect: The Metabolic Requirements …
In contrast to normal differentiated cells, which rely primarily on mitochondrial oxidative phosphorylation to generate the energy needed for cellular processes, most cancer cells instead rely on aerobic glycolysis, a phenomenon termed “the Warburg effect.”
The Warburg effect: 80 years on - PMC - PubMed Central (PMC)
Otto Warburg first described in the 1920s that cancer cells utilised higher levels of glucose in the presence of oxygen with an associated increase in lactate production.
A century of the Warburg effect | Nature Metabolism
2023年11月21日 · In 1923, Otto Warburg published his landmark study, in which he described his seminal observations related to metabolic shifts in cancer, often referred to as the Warburg effect. His work laid...
The Warburg effect version 2.0 - PMC - National Center for ...
2013年4月4日 · Here we propose that a profound understanding of how human carcinomas install a proper “Warburg effect version 2.0” allowing them to “run” the CSCs’ “software” programs should guide a new era of metabolo-genomic-personalized cancer medicine.
The Warburg effect: a signature of mitochondrial overload - Cell …
2023年4月26日 · A long-standing question in cancer biology has been why oxygenated tumors ferment the majority of glucose they consume to lactate rather than oxidizing it in their mitochondria, a phenomenon known as the ‘Warburg effect.’
The Warburg Effect: How Does it Benefit Cancer Cells?
2016年1月5日 · Here, we analyze several proposed explanations for the function of Warburg Effect, emphasize their rationale, and discuss their controversies. Both glycolytic and mitochondrial metabolism are essential for cell proliferation in both past and present conceptions of the Warburg Effect.
Understanding the Warburg effect: the metabolic requirements …
2009年5月22日 · In contrast to normal differentiated cells, which rely primarily on mitochondrial oxidative phosphorylation to generate the energy needed for cellular processes, most cancer cells instead rely on aerobic glycolysis, a phenomenon termed "the Warburg effect."