A quantitative proteomic analysis reveals the potential roles of PRDX3 in neurite outgrowth in N2a-APPswe cells
- DOI: 10.1016/j.bbrc.2022.03.021
- 已发布: 2022/05/14
- Keywords: Mitochondria; Neurite outgrowth; PRDX3; Prot…
- Authors: Benhong Xu
- 页数: 7
Alzheimer's disease (AD) is characterized by amyloid plaques and neurofibrillary tangles accompanied by progressive neurite loss. Mitochondria play pivotal roles in AD development. PRDX3 is a mitochondrial peroxide reductase critical for H2O2 scavenging and signal transduction. In this study, we fou...Identification of hyperoxidized PRDX3 as a ferroptosis …
2023年11月2日 · These results suggest that the resistance of PRDX3 −/− cells to ferroptosis was primarily caused by PRDX3 depletion. Notably, this effect was not unique to SV589 cells, as knockout PRDX3 also rendered HT1080 cells more …
2023年10月19日 · hyperoxidized peroxiredoxin 3 (PRDX3) as a marker for ferroptosis both in vitro and in vivo. During ferropto-sis, mitochondrial lipid peroxides trigger PRDX3 hyperoxidation, a …
- The Affinities of 15 Candidate Compounds with Prdx3 的研究
Identification of hyperoxidized PRDX3 as a ferroptosis marker …
2023年11月2日 · Here, we identify hyperoxidized peroxiredoxin 3 (PRDX3) as a marker for ferroptosis both in vitro and in vivo. During ferroptosis, mitochondrial lipid peroxides trigger …
Hyperoxidized PRDX3 as a specific ferroptosis marker - PubMed
A recent study published in Molecular Cell has identified hyperoxidized peroxiredoxin 3 (PRDX3) as a promising marker for ferroptosis, opening up new avenues for monitoring and targeting …
Human mitochondrial peroxiredoxin Prdx3 is dually localized in …
2024年12月1日 · The peroxidase activities of both Prdx3 isoforms (i-Prdx3 and m-Prdx3) were spectrophotometrically determined by the thioredoxin system coupled assay, following the …
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Identification of hyperoxidized PRDX3 as a ferroptosis marker …
During Ferroptosis, mitochondrial lipid peroxides trigger PRDX3 hyperoxidation, a posttranslational modification that converts a Cys thiol to sulfinic or sulfonic acid. Once …
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2023年8月1日 · In OC, PRDX3 is associated with the activation of NF-κB signaling pathway. In renal cancer, HIF-1α acts as a transcriptional repressor regulating PRDX3 expression. In …
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2015年10月26日 · Prdx3 (b, c, i, j) and Prdx5 (f, g, m, n) display very similar patterns of distribution in the rat and marmoset retina, with both antisera strongly staining the inner and …
A quantitative proteomic analysis reveals the potential roles of …
2022年5月14日 · PRDX3 is a mitochondrial peroxide reductase critical for H 2 O 2 scavenging and signal transduction. In this study, we found that PRDX3 knockdown (KD) in the N2a …
The Affinities of 15 Candidate Compounds with Prdx3 的相关 …
