TGF-α is a transforming growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand.

Transforming growth factor-α (TGF-α) is a small, single-chain polypeptide that is expressed by a large subset of developing and adult tissues commonly, but not exclusively, to stimulate the growth, repair, or migration of neighboring epithelial cells.

2016年3月11日 · Transforming Growth Factor alpha (TGF-α) is a protein structurally similar to Epidermal Growth Factor (EGF) and a ligand for EGF-receptors, competing with Epidermal Growth Factors. It has been found in a variety of non-neoplastic and neoplastic disorders where...

Transforming growth factor ([attribution needed], or TGF) is used to describe two classes of polypeptide growth factors, TGFα and TGFβ. The name "Transforming Growth Factor" is somewhat arbitrary, since the two classes of TGFs are not structurally or genetically related to one another, and they act through different receptor mechanisms .

转化生长因子 TGF-β的名称来源于其转化活性，根据不同的细胞系，当与EGF一起施用或不需要添加EGF时，可诱导细胞锚定非依赖性生长。 最先被鉴定并分离的两种转化生长因子是TGF-α和-β（β1）。 但是TGF-α属于 EGF家族，与EGF受体结合，而TGF-β在结构上与TGF-α不同。 当时区分这两种细胞因子的最显著特征是，TGF-β是一种25kD的 二硫键 链接的二聚体，经还原剂（ …

Transforming growth factor alpha (TGF alpha) is a 5.6 kd single-chain polypeptide that acts through binding to the epidermal growth factor receptor (EGFR). TGF alpha is produced in a wide range of normal as well as embryonic and neoplastic cells and tissues.

2024年12月25日 · TGFA (Transforming Growth Factor Alpha) is a Protein Coding gene. Diseases associated with TGFA include Tooth Agenesis and Cleft Lip. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway.