tert-Butyldimethylsilyl chloride is an organosilicon compound with the formula (Me 3 C)Me 2 SiCl (Me = CH 3). It is commonly abbreviated as TBSCl or TBDMSCl. It is a chlorosilane containing two methyl groups and a tert -butyl group. As such it is more bulky that trimethylsilyl chloride.

Tert-butyldimethylsilyl chloride is a silyl chloride consisting of a central silicon atom covalently bound to one chloro, one tert-butyl and two methyl groups. tert-Butyldimethylsilyl chloride is a derivatisation agent used in gas chromatography/mass spectrometry applications. It has a role as a chromatographic reagent.

2025年2月24日 · tert-Butyldimethylchlorosilane is used to protect hydroxyl group in organic synthesis. It finds application in the synthesis of prostaglandin. It is also used as an auxiliary material for hypolipaemics such as lovastatin and simvastatin. It plays an important role in the preparation of isoxazolines N-oxides from alpha-bromonitroalkanes.

tert -Butyldimethylsilyl chloride (TBDMSCl) is an organosilicon compound that can be used as a versatile protecting reagent for alcohols, amines, amides, and various carboxylic acids. [1] [2] It is also used in the preparation of isoxazoline N -oxides from α-bromonitroalkanes and olefins. [3] .

TBS protection by Corey uses TBS-Cl (forms hygroscopic white crystals) in DMF with imidazole or DMAP. Corey encountered challenges using TBS-Cl for protection of tertiary or hindered secondary alcohols. Use of TBS- OTf triflate (with 2,6-lutidine as base in solvents like dichloromethane) proved more potent for such cases.

叔丁基二甲基氯硅烷 (TBDMSCl) 是一种常用的硅烷化剂，是有机合成中应用最为广泛的重要保护基之一。 在核糖核苷的合成中用于羟基的保护基，同时也是氧化剂，脱氰剂。 它可以在温和的条件下与羟基反应生成相应的硅醚，与酮、酯或者酰胺反应生成相应的烯醇硅醚。 硅烷化剂。 有机合成中作为羟基保护剂,衍生化试剂用于分析和制备。 保护叔醇类。 与醇类反应形成硅醚。 测 …

tert-Butyldimethylsilyl chloride is an organosilicon compound with the formula (Me 3 C)Me 2 SiCl (Me = CH 3). It is commonly abbreviated as TBSCl or TBDMSCl. It is a chlorosilane containing two methyl groups and a tert -butyl group. As such it is more bulky that trimethylsilyl chloride.

1-フェニルエタン-1,2-ジオール (276 mg, 2.0 mmol)のジクロロメタン (4 mL, 0.5 mol/L)溶液に トリエチルアミン (0.416 mL, 3.0 mmol)， (362 mg, 2.4 mmol)を加えた後、さらに DMAP (24.4mg, 0.20 mmol)を加え、室温で1.5時間撹拌した。 飽和炭酸水素ナトリウム水溶液 (10 mL)、ジクロロメタン (10 mL)を加えて反応停止した後、反応溶液をジクロロメタン (5 mL x 3)で抽出した …

tert-Butyldimethylsilylchlorid (kurz: TBDMSCl; oft auch weiter verkürzend TBSCl) ist eine chemische Verbindung, die dazu dient, TBS- Schutzgruppen einzuführen. Eine einfache Laborsynthese von tert -Butyldimethylsilylchlorid ist die Reaktion von tert …

When the commercially available tert -butyldimethylsilyl chloride (TBDMS-Cl) was initially used as a silylation agent, it was found by E. J. Corey (J. Am. Chem. Soc. 1972, 94, 6192) to react very slowly and to give unsatisfactory yields with alcohols.