Taxine alkaloids, which are often named under the collective title of taxines, are the toxic chemicals that can be isolated from the yew tree. [2] [3] The amount of taxine alkaloids depends on the species of yew, with Taxus baccata and Taxus cuspidata containing the most. [4]

2023年3月8日 · The yew tree (Taxus baccata) and a related species common to gardeners, Japanese yew (Taxus cuspidata) is known to be one of the most poisonous woody plants in the world, with all components of the tree, excepting the fleshy red part of the berry containing lethal amounts of taxine, a toxic alkaloid found in the yew.

2021年2月11日 · Taxine B has been shown to be more potent than Taxine A in animal models, and is thought to be the primary culprit in yew tree toxicity. Taxines A and B act as both calcium channel and sodium channel antagonists.

Taxine is found in various kinds of the yew plant. The poison is in most parts of the yew plant, but the highest amount is in the seeds. Symptoms may include: Seek immediate medical help. DO NOT make a person throw up unless told to do so by poison control or a health care provider. Get the following information:

2019年12月23日 · Taxus baccata, also known as English yew, is a poison that causes cardiac arrhythmias and can result in death from cardiogenic shock. A 49-year-old gentleman was admitted following yew ingestion with suicidal intent. He was bradycardic at 30 b.p.m. and hypotensive on arrival.

2014年1月2日 · Taxine alkaloids cause fatal poisoning, in particular due to the compound’s toxic effect on the cardiovascular apparatus. The present report describes a case of a man for whom CPR using all available methods, although delayed …

Taxines are the active, poisonous constituents in yew plants (Taxus spp.) and have been implicated in animal and human poisonings. Several taxine alkaloids have been isolated and characterized through the use of high performance liquid chromatography, mass spectroscopy, and nuclear magnetic resonance.

Taxanes are a class of diterpenes. They were originally identified from plants of the genus Taxus (yews), and feature a taxadiene core. Paclitaxel (Taxol) and docetaxel (Taxotere) are widely used as chemotherapy agents. [2][3] Cabazitaxel was FDA approved to treat hormone-refractory prostate cancer.

Two Syndromes associated with Yew Poisoning (both caused primarily by taxine A and B) Symptoms- Death. Severity of yew poisoning depends on: Diagnosis – Finding fragments of yew leaves and twigs in the mouth, stomach and intestines. Necropsy. Typical case of yew poisoning.

2022年12月9日 · Biologically active taxanes, present in small- to medium-sized evergreen conifers of various Taxus species, are widely used for their antioxidant, antimicrobial and anti-inflammatory effects, but mostly for their antitumour effects used in the treatment of solid tumours of the breast, ovary, lung, bladder, prostate, oesophagus and melanoma.