mTOR通路关键调控复合物TSC的结构和酶活机制 - 网易
Jan 14, 2021 · tsc复合体包含三个亚基：tsc1，tsc2以及tbc1d7。 其中TSC2包含一个GTP酶活化蛋白（GTPase activating protein，简称GAP）结构域，将GTP形式的Rheb水解为GDP形式 …
TSC2 Gene - GeneCards | TSC2 Protein | TSC2 Antibody
Dec 25, 2024 · TSC2 (TSC Complex Subunit 2) is a Protein Coding gene. Diseases associated with TSC2 include Lymphangioleiomyomatosis and Focal Cortical Dysplasia, Type Ii. Among …
TSC2 - Wikipedia
Tuberous sclerosis complex 2 (TSC2), also known as tuberin, is a protein that in humans is encoded by the TSC2 gene.
TSC2 gene - MedlinePlus
The TSC2 gene provides instructions for producing a protein called tuberin. Within cells, tuberin interacts with a protein called hamartin, which is produced from the TSC1 gene. These two …
徐彦辉团队《Nature Communications》揭示mTOR通路关键调控 …
Jan 14, 2021 · TSC复合体包含三个亚基：TSC1，TSC2以及TBC1D7。其中TSC2包含一个GTP酶活化蛋白（GTPaseactivatingprotein，简称GAP）结构域，将GTP形式的Rheb水解为GDP形 …
TSC2 is phosphorylated and inhibited by Akt and suppresses …
Aug 12, 2002 · Here, we show that TSC1–TSC2 inhibits the p70 ribosomal protein S6 kinase 1 (an activator of translation) and activates the eukaryotic initiation factor 4E binding protein 1 …
TSC2: filling the GAP in the mTOR signaling pathway - PubMed
The tumor-suppressor proteins TSC1 and TSC2 are associated with an autosomal dominant disorder known as tuberous sclerosis complex (TSC). TSC1 and TSC2 function as a …
结节性硬化症2型_结节性硬化症2型疾病数据库_结节性硬化症2型疾 …
与结节性硬化症2有关的重要基因是tsc2（tsc复合物亚基2），其相关通路/超级通路包括发育内皮素-1/ednra激活egfr和转录雄激素受体核信号传导。 在该疾病的背景下，已提到的药物有多西 …
TSC1/TSC2二聚体及其在细胞生长调控中的作用
Mar 20, 2013 · TSC1/TSC2 heterodimer regulates cell growth, migration, differentiation and plays key role in metabolism and embryo development. The genetic characterization of Tsc1 and …
TSC 复杂亚基 2（TSC2）基因 | MCE - MCE-生物活性分子大师
TSC 复杂亚基 2： 该基因是一种肿瘤抑制基因，编码生长抑制蛋白 tuberin。 Tuberin 与 hamartin 相互作用形成 TSC 蛋白复合物，该复合物在细胞生长的控制中发挥作用。这种 TSC 蛋白复合 …