2021年1月14日 · 结节性硬化症蛋白复合体 （Tuberous Sclerosis Complex, 简称 TSC复合体）是mTORC1信号通路中重要的蛋白质复合体，其整合细胞外各种因素的刺激，负调控mTORC1复合体的活性，起到肿瘤抑制的作用。 TSC复合体包含三个亚基：TSC1，TSC2以及TBC1D7。 其中TSC2包含一个GTP酶活化蛋白（GTPase activating protein，简称GAP）结构域，将GTP形式的Rheb水解为GDP形式的Rheb，导致Rheb失活，不能激活mTORC1的激酶活性，抑制细胞生 …

Tuberous sclerosis complex 2 (TSC2), also known as tuberin, is a protein that in humans is encoded by the TSC2 gene. Mutations in this gene lead to tuberous sclerosis. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases.

2024年12月25日 · TSC2 (TSC Complex Subunit 2) is a Protein Coding gene. Diseases associated with TSC2 include Lymphangioleiomyomatosis and Focal Cortical Dysplasia, Type Ii. Among its related pathways are Translation Insulin regulation of translation and MTOR signalling.

The TSC2 gene provides instructions for producing a protein called tuberin. Within cells, tuberin interacts with a protein called hamartin, which is produced from the TSC1 gene. These two proteins help control cell growth and division (proliferation) and cell size.

The tumor-suppressor proteins TSC1 and TSC2 are associated with an autosomal dominant disorder known as tuberous sclerosis complex (TSC). TSC1 and TSC2 function as a heterodimer to inhibit cell growth and proliferation. Another protein, mTOR (mammalian target of rapamycin), is regarded as a central …

2013年3月20日 · TSC1/TSC2能响应生长因子、胰岛素及各类环境胁迫信号，并发挥其靶向小G蛋白Rheb的GAP（GTPase active protein，GAP）活性，经由Rheb/mTORC1（mammalian target of rapamycin complex1）模式信号途径来调控细胞生长、分化及迁移并在胚胎发育及机体代谢过程中发挥重要的功能。 综述Tsc1和Tsc2 的分子遗传特性及其产物TSC1/TSC2在细胞生长调控中的作用。 https://biotech.aiijournal.com/CN/Y2013/V0/I9/38.

2025年3月4日 · Title: Novel MSH2 and TSC2 variants in a Chinese family with Lynch syndrome and their synergistic impact in urothelial carcinoma. CBAP regulates the function of Akt-associated TSC protein complexes to modulate mTORC1 signaling.

2021年1月14日 · TSC复合体包含三个亚基：TSC1，TSC2以及TBC1D7。其中TSC2包含一个GTP酶活化蛋白（GTPaseactivatingprotein，简称GAP）结构域，将GTP形式的Rheb水解为GDP形式的Rheb，导致Rheb失活，不能激活mTORC1的激酶活性，抑制细胞生长。

结节性硬化症蛋白复合体（Tuberous Sclerosis Complex, 简称TSC复合体）是mTORC1信号通路中重要的蛋白质复合体，其整合细胞外各种因素的刺激，负调控mTORC1复合体的活性，起到肿瘤抑制的作用。 TSC复合体包含三个亚基：TSC1，TSC2以及TBC1D7。 其中TSC2包含一个GTP酶活化蛋白（GTPase activating protein，简称...

2016年5月26日 · Tuberous sclerosis complex (TSC) is an autosomal dominant disorder that affects multiple organ systems and is caused by loss-of-function mutations in one of two genes:...