mTOR通路关键调控复合物TSC的结构和酶活机制 - 网易
2021年1月14日 · 结节性硬化症蛋白复合体 （Tuberous Sclerosis Complex, 简称 TSC复合体）是mTORC1信号通路中重要的蛋白质复合体，其整合细胞外各种因素的刺激，负调控mTORC1 …
TSC2 - Wikipedia
Tuberous sclerosis complex 2 (TSC2), also known as tuberin, is a protein that in humans is encoded by the TSC2 gene. Mutations in this gene lead to tuberous sclerosis. Its gene product …
TSC2 Gene - GeneCards | TSC2 Protein | TSC2 Antibody
2024年12月25日 · TSC2 (TSC Complex Subunit 2) is a Protein Coding gene. Diseases associated with TSC2 include Lymphangioleiomyomatosis and Focal Cortical Dysplasia, Type …
TSC2 gene - MedlinePlus
The TSC2 gene provides instructions for producing a protein called tuberin. Within cells, tuberin interacts with a protein called hamartin, which is produced from the TSC1 gene. These two …
TSC2: filling the GAP in the mTOR signaling pathway - PubMed
The tumor-suppressor proteins TSC1 and TSC2 are associated with an autosomal dominant disorder known as tuberous sclerosis complex (TSC). TSC1 and TSC2 function as a …
TSC1/TSC2二聚体及其在细胞生长调控中的作用
2013年3月20日 · TSC1/TSC2能响应生长因子、胰岛素及各类环境胁迫信号，并发挥其靶向小G蛋白Rheb的GAP（GTPase active protein，GAP）活性，经由Rheb/mTORC1（mammalian …
TSC2 TSC complex subunit 2 [ Homo sapiens (human) ]
2025年3月4日 · Title: Novel MSH2 and TSC2 variants in a Chinese family with Lynch syndrome and their synergistic impact in urothelial carcinoma. CBAP regulates the function of Akt …
徐彦辉团队《Nature Communications》揭示mTOR通路关键调控 …
2021年1月14日 · TSC复合体包含三个亚基：TSC1，TSC2以及TBC1D7。其中TSC2包含一个GTP酶活化蛋白（GTPaseactivatingprotein，简称GAP）结构域，将GTP形式的Rheb水解 …
复旦上医徐彦辉团队揭示mTOR通路关键调控复合物TSC的结构和酶 …
结节性硬化症蛋白复合体（Tuberous Sclerosis Complex, 简称TSC复合体）是mTORC1信号通路中重要的蛋白质复合体，其整合细胞外各种因素的刺激，负调控mTORC1复合体的活性，起 …
Tuberous sclerosis complex - Nature Reviews Disease Primers
2016年5月26日 · Tuberous sclerosis complex (TSC) is an autosomal dominant disorder that affects multiple organ systems and is caused by loss-of-function mutations in one of two genes:...