Transient receptor potential cation channel, subfamily V, member 3, also known as TRPV3, is a human gene encoding the protein of the same name. The TRPV3 protein belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation .

TRPV3 is a central player in regulating physiological skin homeostasis. TRPV3 regulates proliferation, differentiation and apoptosis of human (as well as mouse) epidermal keratinocytes (Cals-Grierson & Ormerod, 2011; Miyamoto et al. 2009; Radtke et al. 2002; Cao et al. 2004). Specifically, its activation results in the inhibition of ...

2023年1月12日 · Transient receptor potential vanillin 3 (TRPV3) is a member of the transient receptor potential (TRP) superfamily. As a Ca 2+ -permeable nonselective cation channel, TRPV3 can recognize thermal stimulation (31-39 °C), and it plays an important regulatory role in temperature perception, pain …

Transient receptor potential vanilloid subtype 3 (TRPV3) is an ion channel with a sensory function that is most abundantly expressed in keratinocytes and peripheral neurons. TRPV3 plays a role in Ca2+ homeostasis due to non-selective ionic ...

The transient receptor potential (TRP) channel TRPV3 plays a crucial role in skin physiology and pathophysiology. Mutations in TRPV3 are associated with various skin diseases, including Olmsted syndrome, atopic dermatitis and rosacea. Here we ...

2002年6月23日 · Here we have identified a member of the vanilloid channel family, human TRPV3 (hTRPV3) that is expressed in skin, tongue, dorsal root ganglion, trigeminal ganglion, spinal cord and brain.

TRPV3 is a temperature-sensitive ion channel protein that functions as a nonselective cation channel activated by warm temperatures, chemicals, and natural compounds. It plays a role in various physiological processes and is expressed in both neuronal and non-neuronal tissues, potentially impacting skin disorders, itch, and pain sensation.

2024年12月25日 · TRPV3 (Transient Receptor Potential Cation Channel Subfamily V Member 3) is a Protein Coding gene. Diseases associated with TRPV3 include Olmsted Syndrome 1 and Palmoplantar Keratoderma, Nonepidermolytic, Focal 2 .

2023年5月11日 · Transient receptor potential vanilloid subtype 3 (TRPV3) is an ion channel with a sensory function that is most abundantly expressed in keratinocytes and peripheral neurons.

2023年8月30日 · High-speed atomic force microscopy single-molecule imaging and cryo-EM analysis discover and reveal the structure of a TRPV3 pentamer, providing evidence for a non-canonical pentameric...