TRPV2 is one type of ion channel that directs T cell activation, proliferation, and defense mechanisms. If the TRPV2 channel were absent or not functioning properly in T cells, T cell receptor signaling would not be optimal. TRPV2 also acts as a transmembrane protein on the surface of B cells, negatively controlling B cell activation. [20]

Transient receptor potential vanilloid type 2, TRPV2, is a calcium-permeable cation channel belonging to the TRPV channel family. This channel is activated by heat (>52 °C), various ligands, and mechanical stresses.

2024年12月25日 · TRPV2 (Transient Receptor Potential Cation Channel Subfamily V Member 2) is a Protein Coding gene. Diseases associated with TRPV2 include Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques and Dentin Sensitivity .

Herein, we focus on the latest advancements in understanding the role of TRPV2, a Ca 2+ permeable channel belonging to the TRPV subfamily in neurogenesis and gliomagenesis. TRPV2 has been found to be expressed in both neural progenitor cells and glioblastoma stem/progenitor-like cells (GSCs).

2019年12月19日 · Here, we review the recent findings on TRPV2 in cardiomyocytes and immune cells involved in the development of heart failure and discuss the current progress of drug development for the treatment...

2022年9月26日 · Despite many TRPV2 modulators being identified, whether and how TRPV2 is regulated by endogenous lipids remains elusive. Here, we report an endogenous cholesterol molecule inside the vanilloid...

Four TRPVs (TRPV1, TRPV2, TRPV3, and TRPV4) are expressed in afferent nociceptors, pain sensing neurons, where they act as transducers of thermal and chemical stimuli.

Transient potential receptor vanilloid 2 (TRPV2) is widely expressed through the nervous system and specifically found in neuronal subpopulations and some glial cells. TRPV2 is known to be sensitized by methionine oxidation, which results from inflammation.

One of the least characterized members of the TRP subfamily is TRPV2. Although initially characterized as a noxious heat sensor, TRPV2 now seems to have little to do with temperature sensing, but a much more complex physiological profile.

2020年12月10日 · The Transient Receptor Potential Vanilloid type-2 (TRPV2) channel exhibits oncogenicity in different types of cancers. TRPV2 is implicated in signaling pathways that mediate cell survival, proliferation, and metastasis.

2022年4月28日 · Here we present cryo-electron microscopy (cryo-EM) structures of rat TRPV2 in lipid nanodiscs activated by 2-aminoethoxydiphenyl borate (2-APB) and propose a TRPV2-specific 2-ABP binding site at...

2024年9月16日 · This comprehensive review aims to elucidate the intricate thermosensitivity of TRPV2 by synthesizing current knowledge on its biophysical properties, expression pattern and known physiological functions associated with thermosensation.

The transient receptor potential vanilloid 2 (TRPV2) channel is a nonselective cation channel that has been implicated in multiple sensory processes in the nervous system. Here, it is shown that TRPV2 in myeloid cells facilitates virus penetration by promoting the tension and mobility of …

2016年2月3日 · This review provides a summary of the physiological significance of the TRPV2 ion channel. While TRPV2 was initially characterized as a noxious heat sensor, we found that TRPV2 can also act as a mechanosensor in embryonic neurons or adult myenteric neurons.

Thermoreceptors perceive the thermal sensation, made up of ionic channels called transient potential receptors (TRP), which detect different temperature ranges (TRPV2, TRPV3, TRPV4, TRPM8, and TRPA1) [8,77].

4 天之前 · TRPV2 is expressed in preosteoclasts and plays a regulatory role in osteoclast differentiation during orthodontic tooth movement. In a study by Sho et al., a rat orthodontic tooth movement model demonstrated that tooth movement induced TRPV2 expression in TRAP-positive monocytes and multinucleated cells on the pressure and tension sides of the ...

2013年4月25日 · Here we outline the current knowledge on transient receptor potential vanilloid 2 (TRPV2) ion channel. Although initially described as a noxious heat thermosensor, its molecular mechanism and regulat...

The PIP2 binding sites are very similar to previously reported in the TRPV1 and TRPV2 structures. These results reaffirm the role of PIP2 as coupling elements regulating the voltage sensing properties of the TRP channels by occupying channel hydrophobic pockets with PIP2’s aliphatic chain. TRP channels have been also reported to be regulated ...

Among these, TRPA1, TRPV1, and TRPV2 function within the noxious (i.e., painful) temperature range, while the others function within the innocuous range (i.e., coolness and warmth). In addition, TRPM3 is a nociceptive heat sensor . More recently, TRPM2 has been reported to be a warmth sensor in mice [42, 43].

2021年6月10日 · Thermoreceptors perceive the thermal sensation, made up of ionic channels called transient potential receptors (TRP), which detect different temperature ranges (TRPV2, TRPV3, TRPV4, TRPM8, and TRPA1) [8,77].