The Transient Receptor Potential Vanilloid 1 (TRPV1) channel is a polymodal protein with functions widely linked to the generation of pain. Several agonists of exogenous and endogenous nature have been described for this ion channel. Nonetheless, ...

Because TRPV1 functions as a molecular integrator for multiple types of sensory input, in this chapter we will explore the molecular mechanisms underlying the activation and modulation of this channel.

The transient receptor potential (TRP) family comprises a diverse group of cation channels that regulate a variety of intracellular signaling pathways. The TRPV1 (vanilloid 1) channel is best known for its role in nociception and sensory ...

TRPV1 is a key bridge in neuroimmune interactions, allowing for smooth and convenient communication between the two systems. Here, we discuss the coordinated cross-talking between the immune and nervous systems and the functional role and the functioning manner of the TRPV1 involved.

2024年12月25日 · TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1) is a Protein Coding gene. Diseases associated with TRPV1 include Cystinosis, Nephropathic and Pulpitis. Among its related pathways are Ion channel transport and CREB Pathway.

2013年12月4日 · Comparison of the closed and open structures suggests that TRPV1 has a unique two-gate mechanism of channel activation.

The TRPV1 (vanilloid 1) channel is best known for its role in nociception and sensory transmission. First studied in the dorsal root ganglia as the receptor for capsaicin, TRPV1 is now recognized to have a broader distribution and function within the central nervous system (CNS).

2020年4月1日 · The Transient Receptor Potential Vanilloid 1 (TRPV1) channel is a polymodal protein with functions widely linked to the generation of pain. Several agonists of exogenous and endogenous nature have been described for this ion channel.

The transient receptor potential vanilloid-1 (TRPV1) is a non-specific cation channel known for its sensitivity to pungent vanilloid compound (i.e. capsaicin) and noxious stimuli, including heat, low pH or inflammatory mediators.

TRPV1 is a non-selective cation channel and polymodal receptor that is activated by capsaicin, endogenous lipids, heat, and mildly acidic pH. It triggers a cascade of events that lead to the transmission of pain signals, making it a potential target for pain management.