中国科技大学眼科中心的董凯团队最近研究利用rd相似的病理生理状态的短暂性全脑缺血(tgci)模型进行实验，用trpml1小分子激动剂激活trpml1可以通过溶酶体自噬诱导减弱神经元死亡。

Physiological studies have described TRPML1 channels as proton leak channels in lysosomes responsible for preventing these organelles from becoming too acidic. [2] TRPML2 and TRPML3 more poorly characterized than TRPML1 .

Mucolipin-1 (ML1) also known as TRPML1 (transient receptor potential cation channel, mucolipin subfamily, member 1) is a protein that in humans is encoded by the MCOLN1 gene. [5] It is a member of the small family of the TRPML channels, a …

trpml1重要功能之一是促进溶酶体转运到细胞膜附近并促进溶酶体分泌，从而促进细胞膜的修复。 通过LAMP1标记发现，当细胞中加入TRPML1激动剂时，溶酶体会显著转运到细胞膜附近，而TRPML1敲除虽然会引起溶酶体数量代偿性增加，但溶酶体转运受损（图3）5。

2019年12月10日 · The lysosomal calcium channel TRPML1, whose mutations cause the lysosomal storage disorder (LSD) mucolipidosis type IV (MLIV), contributes to upregulate autophagic genes by inducing the nuclear...

2017年10月11日 · Transient receptor potential mucolipin 1 (TRPML1) is a Ca2+-releasing cation channel that mediates the calcium signalling and homeostasis of lysosomes. Mutations in TRPML1...

At the cellular level, loss-of-function mutations of mammalian TRPML1 or its C. elegans or Drosophila homolog gene results in lysosomal trafficking defects and lysosome storage. In this chapter, we summarize recent advances in our understandings of the cell biological and channel functions of TRPML1.

2018年1月1日 · TRPML1 has been involved in the regulation of Ca 2+-dependent lysosomal exocytosis (top left). TRPML1 activity has been involved in vesicular fusion events and lysosomal re-formation (bottom left). Upon different environmental cues, such as nutrient deprivation, TRPML1 activation induces TFEB-mediated transcriptional program (top right).

2014年1月1日 · The first member of the mammalian mucolipin TRP channel subfamily (TRPML1) is a cation-permeable channel that is predominantly localized on the membranes of late endosomes and lysosomes (LELs) in all mammalian cell types. In …

2024年1月15日 · TRPML1 is a non-selective cation channel permeable to Ca 2+, Fe 2+ and Zn 2+, with its primary function being to induce Ca 2+ release from endolysosomal compartments. 11, 12 TRPML1 channels are expressed ubiquitously, including all regions of the brain.